Potential new anti-human immunodeficiency virus type 1 compounds depress virus replication in cultured human macrophages

被引：43
|
作者：
Ewart, GD
Nasr, N
Naif, H
Cox, GB
Cunningham, AL
Gage, PW
机构：
[1] Australian Natl Univ, Biotron Ltd, Canberra, ACT 2601, Australia
[2] Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, Australia
[3] Westmead Millenium Inst, Westmead, NSW 2145, Australia
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2004年 / 48卷 / 06期
关键词：
D O I：
10.1128/AAC.48.6.2325-2330.2004
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We report that the amiloride analogues 5-(N,N'-hexamethylene)amiloride and 5-(N,N'-dimethyl)amiloride inhibit, at micromolar concentrations, the replication of human immunodeficiency virus type 1 (HIV-1) in cultured human blood monocyte-derived macrophages. These compounds also inhibit the in vitro activities of the HIV-1 Vpu protein and might represent lead compounds for a new class of anti-HIV-1 drugs.
引用
收藏
页码：2325 / 2330
页数：6
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