Highly efficient synthesis of bioactive oleanane-type saponins

被引：9
|
作者：
Sui, Jing-Jing [1 ]
Zhou, Wen-Hui [2 ]
Liu, De-Yong [1 ]
Li, Ming-Qing [2 ]
Sun, Jian-Song [1 ]
机构：
[1] Jiangxi Normal Univ, Natl Res Ctr Carbohydrate Synth, 99 Ziyang Ave, Nanchang 330022, Jiangxi, Peoples R China
[2] Fudan Univ, Shanghai Med Coll, Hosp Obstet & Gynecol, Lab Reprod Immunol, Shanghai 200011, Peoples R China
来源：
CARBOHYDRATE RESEARCH | 2017年 / 452卷
关键词：
TRITERPENOID SAPONINS; MEDICINAL FOODSTUFFS; ADJUVANT ACTIVITY; FACILE SYNTHESIS; RAIN-FOREST; GLYCOSIDES; OLIGOSACCHARIDES; CYTOTOXICITY; LABLABOSIDES; CONSTITUENTS;
D O I：
10.1016/j.carres.2017.08.010
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Leveraging on Schmidt glycosylation method, a highly efficient approach to obtain oleanane-type triterpene saponins was fixed, whereby oleanyl mono-, disaccharide (guaianin N), trisaccharide (elatoside E), as well as tetrasaccharide (elatoside F) were obtained efficiently. The synthetic investigation has resulted in the discovery of the effect of branch-sugar incorporation sequence on the overall synthetic efficiency. Moreover, through bioactivity investigation, the cytotoxic activity of the obtained triterpenoid saponins was evaluated, and the preliminary structure-activity relationship was deduced. (C) 2017 Published by Elsevier Ltd.
引用
收藏
页码：43 / 46
页数：4
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