Biochemical characterization of antigens detected with anti-platelet monoclonal antibodies

被引：10

作者：

Mateo, A ^{[1
]}

delaLastra, JP ^{[1
]}

Moreno, A ^{[1
]}

Dusinsky, R ^{[1
]}

Bilka, F ^{[1
]}

Simon, M ^{[1
]}

Horovska, L ^{[1
]}

Llanes, D ^{[1
]}

机构：

[1] SLOVAK ACAD SCI,INST ANIM BIOCHEM & GENET,CR-90028 IVANKA PRI DUNAJ,CZECH REPUBLIC

来源：

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY | 1996年 / 52卷 / 04期

关键词：

D O I：

10.1016/0165-2427(96)05588-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A panel of 18 monoclonal antibodies (mAbs) defined by the third workshop as specific for platelets, clustered in three preliminary groups: PC7, PC13 and PC27, These mAbs were further analysed by immunoprecipitation using extracts of iodinated and biotinylated peripheral blood mononucleated cells (PBMC) and platelets. We could confirm the existence of mAbs with specificities to WC9 (in PC7) and CD41/61 (in PC13). Two mAbs formed a new cluster, WC13, which may be homologous to human CD31 (in PC27). The influence of EDTA and thrombin on the expression of the different antigens on the platelet membrane was assessed by flow cytometry (FCM) analysis, as well as cross-reactivity with platelets from different species.

引用

页码：363 / 370

页数：8

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