Estimating the community prevalence, child traits, and maternal risk factors of fetal alcohol spectrum disorders (FASD) from a random sample of school children

被引:22
|
作者
May, Philip A. [1 ,4 ]
Hasken, Julie M. [1 ]
Hooper, Stephen R. [2 ]
Hedrick, Dixie M. [1 ]
Jackson-Newsom, Julia [3 ]
Mullis, Chalise E. [3 ]
Dobyns, Elizabeth [3 ]
Kalberg, Wendy O. [4 ]
Buckley, David [4 ]
Robinson, Luther K. [5 ]
Abdul-Rahman, Omar [6 ]
Adam, Margaret P. [7 ]
Manning, Melanie A. [8 ]
Jewett, Tamison [9 ]
Hoyme, H. Eugene [10 ,11 ]
机构
[1] Univ North Carolina Chapel Hill, Nutr Res Inst, Kannapolis, NC 28081 USA
[2] Univ N Carolina, Dept Allied Hlth Sci, Sch Med, Chapel Hill, NC USA
[3] Univ N Carolina, Off Vice Chancellor Res, Greensboro, NC USA
[4] Univ New Mexico, Ctr Alcoholism Subst Abuse & Addict, Albuquerque, NM 87131 USA
[5] SUNY Buffalo, Dept Pediat, Buffalo, NY USA
[6] Univ Nebraska Med Ctr, Munroe Meyer Inst, Dept Genet Med, Omaha, NE USA
[7] Univ Washington, Dept Pediat, Div Genet Med, Seattle, WA 98195 USA
[8] Stanford Univ, Dept Pediat, Sch Med, Stanford, CA USA
[9] Wake Forest Univ, Dept Pediat, Winston Salem, NC USA
[10] Univ Arizona, Coll Med, Dept Pediat, Tucson, AZ USA
[11] Sanford Hlth, Sanford Childrens Genom Med Consortium, Sioux Falls, SD USA
基金
美国国家卫生研究院;
关键词
Fetal alcohol spectrum disorders; Prevalence; Alcohol use; Women; Prenatal alcohol use; Children with FASD; Maternal risk traits for FASD; SOUTH-AFRICAN COMMUNITY; EPIDEMIOLOGY; DRINKING; PROVINCE; ASCERTAINMENT; RELIABILITY; CONSUMPTION; CONTINUUM; BIRTH;
D O I
10.1016/j.drugalcdep.2021.108918
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
Objective: Utilize a random sample to estimate the prevalence, child traits, and maternal risk for fetal alcohol spectrum disorders (FASD) in a Southeastern United States county. Methods: From all first-grade students (n = 1073) a simple random sample was drawn, and 32 % (n = 231) were consented. All 231 children were examined for dysmorphology and growth, 84 were tested and rated on neurobehavior, and 72 mothers were interviewed for maternal risk. Results: Significant differences (alpha = .05) between the physical traits of children diagnosed with FASD and the entire sample were height, weight, head circumference, body mass index, and total dysmorphology scores, and all three cardinal features of fetal alcohol syndrome: palpebral fissure length, smooth philtrum, and narrow vermilion. Intellectual function and inhibition were not significantly different between FASD and typicallyfunctioning children, but two executive function measures and one visual/spatial measure approached significance (alpha = .10). Three behavioral measures were significantly worse for the FASD group: parent-rated problems of communication, daily living, and socialization. Significant maternal risk factors reported were postpartum depression, frequency of drinking, and recovery from problem drinking. The prevalence of FASD was 71.4 per 1,000 or 7.1 %. This rate falls clearly within the prevalence range identified in eight larger samples of other communities in the Collaboration on FASD Prevalence (CoFASP) study in four regions of the United States. Conclusion: Careful and detailed clinical evaluation of children from small random samples can be useful for estimating the prevalence and traits of FASD in a community.
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页数:12
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