Breastfeeding and maternal alcohol use: Prevalence and effects on child outcomes and fetal alcohol spectrum disorders

被引：51

作者：

May, Philip A. ^{[1
,2
,3
]}

Hasken, Julie M. ^{[1
]}

Blankenship, Jason ^{[2
]}

Marais, Anna-Susan ^{[3
]}

Joubert, Belinda ^{[3
]}

Cloete, Marise ^{[3
]}

de Vries, Marlene M. ^{[3
]}

Barnard, Ronel ^{[3
]}

Botha, Isobel ^{[3
]}

Roux, Sumien ^{[3
]}

Doms, Cate ^{[3
]}

Gossage, J. Phillip ^{[2
]}

Kalberg, Wendy O. ^{[2
]}

Buckley, David ^{[2
]}

Robinson, Luther K. ^{[4
]}

Adnams, Colleen M. ^{[5
]}

Manning, Melanie A. ^{[6
,7
]}

Parry, Charles D. H. ^{[3
,8
]}

Hoyme, H. Eugene ^{[9
]}

Tabachnick, Barbara ^{[10
]}

Seedat, Soraya ^{[3
]}

机构：

[1] Univ N Carolina, Inst Nutr Res, Chapel Hill, NC USA

[2] Univ New Mexico, Ctr Alcoholism Subst Abuse & Addict, Albuquerque, NM 87131 USA

[3] Univ Stellenbosch, Fac Med & Hlth Sci, ZA-7600 Stellenbosch, South Africa

[4] SUNY Buffalo, Dept Pediat, Buffalo, NY USA

[5] Univ Cape Town, Dept Psychiat & Mental Hlth, ZA-7700 Rondebosch, South Africa

[6] Stanford Univ, Dept Pathol, Sch Med, Stanford, CA 94305 USA

[7] Stanford Univ, Dept Pediat, Sch Med, Stanford, CA 94305 USA

[8] Med Res Council South Africa, Alcohol Tobacco & Other Drug Res Unit, Cape Town, South Africa

[9] Univ South Dakota, Sanford Res, Sanford Sch Med, Dept Pediat, Vermillion, SD USA

[10] Calif State Univ Northridge, Northridge, CA 91330 USA

来源：

REPRODUCTIVE TOXICOLOGY | 2016年 / 63卷

基金：

美国国家卫生研究院;

关键词：

Breastfeeding; Alcohol; Fetal alcohol spectrum disorders (FASD); Pregnancy; Child health and development; SOUTH-AFRICAN COMMUNITY; IRON-DEFICIENCY ANEMIA; WESTERN CAPE PROVINCE; RISK-FACTORS; NUTRITIONAL-STATUS; CONSUMPTION; INFANT; EPIDEMIOLOGY; EXPOSURE; WOMEN;

D O I：

10.1016/j.reprotox.2016.05.002

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Objective: Determine any effects that maternal alcohol consumption during the breastfeeding period has on child outcomes. Methods: Population-based samples of children with fetal alcohol spectrum disorders (FASD), normally developing children, and their mothers were analyzed for differences in child outcomes. Results: Ninety percent (90%) of mothers breastfed for an average of 19.9 months. Of mothers who drank postpartum and breastfed (MDPB), 47% breastfed for 12 months or more. In case control analyses, children of MDPB were significantly lighter, had lower verbal IQ scores, and more anomalies in comparisons controlling for prenatal alcohol exposure and final FASD diagnosis. Utilizing a stepwise logistic regression model adjusting for nine confounders of prenatal drinking and other maternal risks, MDPB were 6.4 times more likely to have a child with FASD than breastfeeding mothers who abstained from alcohol while breastfeeding. Conclusions: Alcohol use during the period of breastfeeding was found to significantly compromise a child's development. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：13 / 21

页数：9

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