Modeling protein-DNA complexes with tangles

被引：9
|
作者：
Darcy, Isabel K. [1 ]
机构：
[1] Univ Iowa, Dept Math, Iowa City, IA 52242 USA
来源：
COMPUTERS & MATHEMATICS WITH APPLICATIONS | 2008年 / 55卷 / 05期
基金：
美国国家卫生研究院;
关键词：
tangle; topoisomerase; recombinase; DNA knot; unknotting number;
D O I：
10.1016/j.camwa.2006.12.099
中图分类号：
O29 [应用数学];
学科分类号：
070104 ;
摘要：
The mathematics of tangles has been applied to model protein-DNA binding. A tangle consists of strings properly embedded in a 3-dimensional ball. The protein complex can be thought of as a 3D ball while the DNA segments bound by the protein complex can be thought of as strings embedded within the ball. This simple model can be used to determine the topology of protein-bound DNA. We review some tangle models and related software for modeling recombinase and topoisomerase action. (c) 2008 Published by Elsevier Ltd.
引用
收藏
页码：924 / 937
页数：14
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