Toward enzyme-responsive polymersome drug delivery

被引:8
|
作者
Paruchuri, Bipin Chakravarthy [1 ]
Gopal, Varun [1 ,2 ]
Sarupria, Sapna [1 ,3 ,4 ]
Larsen, Jessica [1 ,5 ]
机构
[1] Clemson Univ, Dept Chem & Biomol Engn, Clemson, SC 29631 USA
[2] Univ Minnesota, Dept Chem Engn & Mat Sci, 421 Washington Ave SE, Minneapolis, MN 55455 USA
[3] Clemson Univ, Ctr Opt Mat Sci & Engn Technol, Clemson, SC 29670 USA
[4] Univ Minnesota, Dept Chem, 207 Pleasant St SE, Minneapolis, MN 55455 USA
[5] Clemson Univ, Dept Bioengn, Clemson, SC 29631 USA
基金
美国国家科学基金会;
关键词
computer simulations; drug delivery; enzyme responsiveness; morphology phase diagrams; nanomedicine; nanoparticles; polymersomes; stimuli responsiveness; AQUEOUS DISPERSION POLYMERIZATION; DISSIPATIVE PARTICLE DYNAMICS; BLOCK-COPOLYMER; PHASE-DIAGRAMS; POLY(ETHYLENE GLYCOL); MOLECULAR-DYNAMICS; IN-VITRO; VESICLES; DEGRADATION; SIMULATION;
D O I
10.2217/nnm-2021-0194
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
In drug delivery, enzyme-responsive drug carriers are becoming increasingly relevant because of the growing association of disease pathology with enzyme overexpression. Polymersomes are of interest to such applications because of their tunable properties. While polymersomes open up a wide range of chemical and physical properties to explore, they also present a challenge in developing generalized rules for the synthesis of novel systems. Motivated by this issue, in this perspective, we summarize the existing knowledge on enzyme-responsive polymersomes and outline the main design choices. Then, we propose heuristics to guide the design of novel systems. Finally, we discuss the potential of an integrated approach using computer simulations and experimental studies to streamline this design process and close the existing knowledge gaps. Tweetable abstract: How can we optimize the design of enzyme-responsive polymersomes to better treat disease? In this perspective, three common modes of enzymatic action in these nanoparticles are identified.
引用
收藏
页码:2679 / 2693
页数:15
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