The Evolving Context of Driver Mutations: ROS1 Rearrangement in Metastatic Non-Small Cell Lung Cancer

被引:0
|
作者
DeCaire, Ximena [1 ]
Streu, Erin [1 ]
机构
[1] CancerCare Manitoba, Winnipeg, MB, Canada
关键词
ambulatory care/office nursing; biotherapy/targeted therapies; clinical practice; lung cancer; CRIZOTINIB; ADENOCARCINOMA; FUSIONS;
D O I
10.1188/16.ONF.544-547
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The discovery of driver mutations in non-small cell lung cancer (NSCLC) has led to the advent of targeted therapy and changed the clinical landscape. ROS1 is a rare driver mutation found in 1%-2% of patients diagnosed with NSCLC. This case highlights a young woman of Asian descent with no history of smoking diagnosed with NSCLC and ROS1 rearrangement and discusses the implications for oncology nurses in clinical practice.
引用
收藏
页码:544 / 547
页数:4
相关论文
共 50 条
  • [41] CLINICAL ACTIVITY OF CRIZOTINIB IN PATIENTS WITH ADVANCED NON-SMALL CELL LUNG CANCER (NSCLC) HARBORING ROS1 GENE REARRANGEMENT
    Ou, S. I.
    Camidge, D. R.
    Engelman, J.
    Clark, J.
    Tye, L.
    Wilner, K.
    Stephenson, P.
    Varella-Garcia, M.
    Iafrate, A.
    Shaw, A. T.
    ANNALS OF ONCOLOGY, 2012, 23 : 389 - 389
  • [42] ROS1 FUSION GENES: POTENTIAL DRUG TARGETS IN NON-SMALL CELL LUNG CANCER
    Davies, Kurtis D.
    Le, Anh T.
    Theodoro, Mariana F.
    Skokan, Margaret C.
    Aisner, Dara L.
    Terracciano, Luigi M.
    Incarbone, Matteo
    Roncalli, Massimo
    Cappuzzo, Federico
    Camidge, Ross D.
    Doebele, Robert C.
    Garcia, Marileila V.
    JOURNAL OF THORACIC ONCOLOGY, 2012, 7 (07) : S146 - S146
  • [43] Comprehensive Profiling of ROS1 Fusions in Chinese Non-Small Cell Lung Cancer Patients
    Xu, H.
    Fan, X.
    Tian, K.
    Liang, X.
    Li, J.
    Cheng, Y.
    Zhang, S.
    JOURNAL OF THORACIC ONCOLOGY, 2021, 16 (03) : S686 - S686
  • [44] Entrectinib in Patients with Locally Advanced or Metastatic ROS1 Fusion-Positive Non-Small Cell Lung Cancer (NSCLC)
    Ahn, M.
    Cho, B. C.
    Siena, S.
    Drilon, A.
    De Braud, F.
    Krebs, M.
    John, T.
    Karapetis, C.
    Johnson, A.
    Chow-Maneval, E.
    Multani, P.
    Doebele, R.
    JOURNAL OF THORACIC ONCOLOGY, 2017, 12 (11) : S1783 - S1783
  • [45] ROS1 gene rearrangement and copy number gain in non-small cell lung cancer (vol 466, pg 45, 2015)
    Jin, Yan
    Sun, Ping-Li
    Kim, Hyojin
    Park, Eunhyang
    Shim, Hyo Sup
    Jheon, Sanghoon
    Kim, Kwhanmien
    Lee, Choon-Taek
    Chung, Jin-Haeng
    VIRCHOWS ARCHIV, 2015, 467 (01) : 123 - 123
  • [46] Immunotherapy in non-small cell lung cancer harbouring driver mutations
    Addeo, Alfredo
    Passaro, Antonio
    Malapelle, Umberto
    Banna, Giuseppe Luigi
    Subbiah, Vivek
    Friedlaender, Alex
    CANCER TREATMENT REVIEWS, 2021, 96
  • [47] Concomitant Driver Gene Mutations in Non-Small Cell Lung Cancer
    Wang, J.
    Song, H.
    Zhao, Z.
    Zhang, Y.
    Cui, L.
    Bai, Y.
    JOURNAL OF THORACIC ONCOLOGY, 2021, 16 (03) : S423 - S424
  • [48] Non-small cell lung cancer with double driver mutations.
    Osoegawa, Atsushi
    Toyokawa, Gouji
    Ohba, Taro
    Miyawaki, Michiyo
    Yamaguchi, Masafumi
    Taguchi, Kenichi
    Seto, Takashi
    Takenoyama, Mitsuhiro
    Ichinose, Yukito
    Sugio, Kenji
    CLINICAL CANCER RESEARCH, 2014, 20
  • [49] Efficacy of lorlatinib in patients (pts) with ROS1-positive advanced non-small cell lung cancer (NSCLC) and ROS1 kinase domain mutations
    Solomon, B. J.
    Martini, J-F.
    Ou, S-H. I.
    Chiari, R.
    Soo, R. A.
    Bearz, A.
    Li, S.
    Thurm, H.
    Lin, C-C.
    Riely, G. J.
    Bauer, T. M.
    Shaw, A. T.
    ANNALS OF ONCOLOGY, 2018, 29 : 495 - 495
  • [50] Prevalence of Non-driver Mutations and Characterization of Patients with Advanced or Metastatic Non-small Cell Lung Cancer
    Provencio, M.
    Parente, D. Perez
    Hasan, H.
    Balea, B. Campos
    Abreu, D. Rodriguez
    Piqueras, M. Lopez Brea
    Olson, S.
    Pal, N.
    Wilkinson, S.
    de Oro-Pulido, F.
    Gracia, P. Ruiz
    Dols, M. Cobo
    JOURNAL OF THORACIC ONCOLOGY, 2022, 17 (09) : S370 - S371