Lifespan regulation of conventional protein kinase C isotypes

被引：9

作者：

Carmena, D. ^{[1
]}

Sardini, A. ^{[1
]}

机构：

[1] Imperial Coll London, Fac Med, MRC, Clin Sci Ctr, London W12 0NN, England

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2007年 / 35卷

关键词：

conventional protein kinase C (cPKC); degradation; diacylglycerol (DAG); enzyme litespan; internalization; ubiquitination;

D O I：

10.1042/BST0351043

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Plasma membrane translocation, following allosteric binding of second messengers, initiates the signal transduction process mediated by cPKC [conventional PKC (protein kinase C)] isotypes. Mechanisms regulating the lifespan of the active enzyme such as its phosphorylation, internalization, dephosphorylation and degradation are key elements of the signalling network. The understanding of such mechanisms is essential for the design of therapeutic strategies targeting PKC isoenzymes.

引用

页码：1043 / 1045

页数：3

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