Lifespan regulation of conventional protein kinase C isotypes

被引：9

作者：

Carmena, D. ^{[1
]}

Sardini, A. ^{[1
]}

机构：

[1] Imperial Coll London, Fac Med, MRC, Clin Sci Ctr, London W12 0NN, England

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2007年 / 35卷

关键词：

conventional protein kinase C (cPKC); degradation; diacylglycerol (DAG); enzyme litespan; internalization; ubiquitination;

D O I：

10.1042/BST0351043

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Plasma membrane translocation, following allosteric binding of second messengers, initiates the signal transduction process mediated by cPKC [conventional PKC (protein kinase C)] isotypes. Mechanisms regulating the lifespan of the active enzyme such as its phosphorylation, internalization, dephosphorylation and degradation are key elements of the signalling network. The understanding of such mechanisms is essential for the design of therapeutic strategies targeting PKC isoenzymes.

引用

页码：1043 / 1045

页数：3

共 50 条

[1] Multisite dephosphorylation and desensitization of conventional protein kinase C isotypes
Hansra, G
Garcia-Paramio, P
Prevostel, C
Whelan, RDH
Bornancin, F
Parker, PJ
BIOCHEMICAL JOURNAL, 1999, 342 : 337 - 344
[2] Protein kinase C isotypes in C-elegans
Tabuse, Y
JOURNAL OF BIOCHEMISTRY, 2002, 132 (04): : 519 - 522
[3] Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes
Schönwasser, DC
Marais, RM
Marshall, CJ
Parker, PJ
MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (02) : 790 - 798
[4] DIFFERENTIAL REGULATION OF GLYCOGEN-SYNTHASE KINASE-3-BETA BY PROTEIN-KINASE-C ISOTYPES
GOODE, N
HUGHES, K
WOODGETT, JR
PARKER, PJ
JOURNAL OF BIOLOGICAL CHEMISTRY, 1992, 267 (24) : 16878 - 16882
[5] ISOTYPES OF PROTEIN-KINASE-C IN BOVINE SPERM
CHAUDHRY, PS
CASILLAS, ER
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1992, 295 (02) : 268 - 272
[6] Protein kinase C isotypes and their specific functions: Prologue
Ohno, S
Nishizuka, Y
JOURNAL OF BIOCHEMISTRY, 2002, 132 (04): : 509 - 511
[7] The myristoylated alanine-rich C-kinase substrate (MARCKS) is sequentially phosphorylated by conventional, novel and atypical isotypes of protein kinase C
Herget, T.
Oehrlein, S. A.
Pappin, D. J. C.
Rozengurt, E.
European Journal of Biochemistry, 233 (02):
[8] Mutual regulation of conventional protein kinase C and a ubiquitin ligase complex
Nakamura, Munehiro
Tokunaga, Fuminori
Sakata, Shin-ichi
Iwai, Kazuhiro
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2006, 351 (02) : 340 - 347
[9] Protein kinase C (PKC)α and PKCθ are the major PKC isotypes involved in TCR down-regulation
von Essen, Marina
Nielsen, Martin W.
Bonefeld, Charlotte M.
Boding, Lasse
Larsen, Jeppe M.
Leitges, Michael
Baier, Gottfried
Odum, Niels
Geisler, Carsten
JOURNAL OF IMMUNOLOGY, 2006, 176 (12): : 7502 - 7510
[10] THE MYRISTOYLATED ALANINE-RICH C-KINASE SUBSTRATE (MARCKS) IS SEQUENTIALLY PHOSPHORYLATED BY CONVENTIONAL, NOVEL AND ATYPICAL ISOTYPES OF PROTEIN-KINASE-C
HERGET, T
OEHRLEIN, SA
PAPPIN, DJC
ROZENGURT, E
PARKER, PJ
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1995, 233 (02): : 448 - 457

← 1 2 3 4 5 →