Secondary Progressive Multiple Sclerosis: Definition and Measurement

被引：24

作者：

Plantone, Domenico ^{[1
]}

De Angelis, Floriana ^{[1
]}

Doshi, Anisha ^{[1
]}

Chataway, Jeremy ^{[1
]}

机构：

[1] UCL, Dept Neuroinflammat, Queen Sq Multiple Sclerosis Ctr, UCL Inst Neurol, London WC1N 3BG, England

来源：

CNS DRUGS | 2016年 / 30卷 / 06期

关键词：

GRAY-MATTER ATROPHY; CENTRAL-NERVOUS-SYSTEM; BRAIN ATROPHY; FUNCTIONAL COMPOSITE; WHITE-MATTER; COGNITIVE IMPAIRMENT; CLINICAL-TRIALS; NATURAL-HISTORY; SPINAL-CORD; MENINGEAL INFLAMMATION;

D O I：

10.1007/s40263-016-0340-9

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Secondary progressive multiple sclerosis (SPMS) is diagnosed retrospectively and involves a clinical course characterized by a progressive accumulation of neurological disability, independent of relapses, following an initial relapsing-remitting (RR) phase. Our incomplete understanding of the pathological mechanisms underlying neurodegeneration in multiple sclerosis (MS) may explain why, to date, there is no definitive imaging or laboratory test that is able to inform us when the disease is clearly entering into a progressive phase and why the vast majority of clinical trials testing immunosuppressant and immunomodulating drugs in SPMS patients has so far yielded disappointing or mixed results. Here we discuss the definition(s) of SPMS and how it may vary, outcome measurements (current and emerging) and modern trial design.

引用

页码：517 / 526

页数：10

共 50 条

[41] Functional MRI in secondary progressive multiple sclerosis
Gavazzi, C
Rocca, MA
Mezzapesa, DM
Falini, A
Colombo, B
Mascalchi, M
Scotti, G
Comi, G
Filippi, M
[J]. RIVISTA DI NEURORADIOLOGIA, 2003, 16 : 250 - 250
[42] The natural history of secondary progressive multiple sclerosis
Koch, Marcus
Kingwell, Elaine
Rieckmann, Peter
Tremlett, Helen
[J]. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2010, 81 (09): : 1039 - 1043
[43] Mechanisms of disability progression in primary progressive multiple sclerosis: are they different from secondary progressive multiple sclerosis?
Rudick, R
[J]. MULTIPLE SCLEROSIS, 2003, 9 (02): : 210 - 212
[44] Multiple sclerosis impairment scale and brain MRI in secondary progressive multiple sclerosis
Theodorsdottir, Asta
Larsen, Pia Veldt
Nielsen, Helle Hvilsted
Illes, Zsolt
Ravnborg, Mads Henrik
[J]. ACTA NEUROLOGICA SCANDINAVICA, 2022, 145 (03): : 332 - 347
[45] Oral Masitinib in Patients with Primary Progressive or Secondary Progressive Multiple Sclerosis
Vermersch, Patrick
Benrabah, Rabah
Schmidt, Nicolas
Zephir, Helene
Chen, Pierre
Vongsouthi, Cyrille
Moussy, Alain
Hermine, Olivier
[J]. NEUROLOGY, 2009, 72 (11) : A313 - A314
[46] Psychological functioning in primary progressive versus secondary progressive multiple sclerosis
Vleugels, L
Pfennings, L
Pouwer, F
Cohen, L
Ketelaer, P
Polman, C
Lankhorst, G
van der Ploeg, H
[J]. BRITISH JOURNAL OF MEDICAL PSYCHOLOGY, 1998, 71 : 99 - 106
[47] Clinical and laboratory features of primary progressive and secondary progressive multiple sclerosis
Bashir, K
Layton, B
Whatley, W
Whitaker, JN
[J]. ANNALS OF NEUROLOGY, 1998, 44 (03) : 466 - 466
[48] Risk of transition to secondary progressive multiple sclerosis and accumulation of disability in progressive multiple sclerosis are not influenced by current therapies
Alcala, C.
Gascon, F.
Perez-Miralles, F-C.
Escutia, M.
Coret, F.
Casanova, B.
[J]. MULTIPLE SCLEROSIS JOURNAL, 2017, 23 : 702 - 702
[49] Mitoxantrone versus cyclophosphamide in secondary progressive multiple sclerosis
Perini, P
Calabrese, M
Tiberio, M
Laroni, A
Battistin, L
Gallo, P
[J]. MULTIPLE SCLEROSIS, 2005, 11 : S171 - S171
[50] Compromise of the cognitive functions in progressive secondary multiple sclerosis
Andreu-Catala, M.
Pascual-Lozano, A. M.
Bueno-Cayo, A.
Bosca-Blasco, I.
Coret-Ferrer, F.
Casanova-Estruch, B.
[J]. REVISTA DE NEUROLOGIA, 2008, 46 (11) : 664 - 666

← 1 2 3 4 5 →