Secondary Progressive Multiple Sclerosis: Definition and Measurement

被引：24
|
作者：
Plantone, Domenico [1 ]
De Angelis, Floriana [1 ]
Doshi, Anisha [1 ]
Chataway, Jeremy [1 ]
机构：
[1] UCL, Dept Neuroinflammat, Queen Sq Multiple Sclerosis Ctr, UCL Inst Neurol, London WC1N 3BG, England
来源：
CNS DRUGS | 2016年 / 30卷 / 06期
关键词：
GRAY-MATTER ATROPHY; CENTRAL-NERVOUS-SYSTEM; BRAIN ATROPHY; FUNCTIONAL COMPOSITE; WHITE-MATTER; COGNITIVE IMPAIRMENT; CLINICAL-TRIALS; NATURAL-HISTORY; SPINAL-CORD; MENINGEAL INFLAMMATION;
D O I：
10.1007/s40263-016-0340-9
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Secondary progressive multiple sclerosis (SPMS) is diagnosed retrospectively and involves a clinical course characterized by a progressive accumulation of neurological disability, independent of relapses, following an initial relapsing-remitting (RR) phase. Our incomplete understanding of the pathological mechanisms underlying neurodegeneration in multiple sclerosis (MS) may explain why, to date, there is no definitive imaging or laboratory test that is able to inform us when the disease is clearly entering into a progressive phase and why the vast majority of clinical trials testing immunosuppressant and immunomodulating drugs in SPMS patients has so far yielded disappointing or mixed results. Here we discuss the definition(s) of SPMS and how it may vary, outcome measurements (current and emerging) and modern trial design.
引用
收藏
页码：517 / 526
页数：10
相关论文
共 50 条
  • [1] Secondary Progressive Multiple Sclerosis: Definition and Measurement
    Domenico Plantone
    Floriana De Angelis
    Anisha Doshi
    Jeremy Chataway
    [J]. CNS Drugs, 2016, 30 : 517 - 526
  • [2] An EDSS-based definition of secondary progressive multiple sclerosis
    Diaz-Cruz, C.
    Chua, A. S.
    Healy, B. C.
    Sattarnezhad, N.
    Glanz, B. I.
    Weiner, H. L.
    Chitnis, T.
    [J]. MULTIPLE SCLEROSIS JOURNAL, 2016, 22 : 107 - 108
  • [3] Secondary progressive multiple sclerosis - from neuropathology to definition and effective treatment
    Adamczyk-Sowa, Monika
    Adamczyk, Bozena
    Kulakowska, Alina
    Rejdak, Konrad
    Nowacki, Przemyslaw
    [J]. NEUROLOGIA I NEUROCHIRURGIA POLSKA, 2020, 54 (05) : 384 - 398
  • [4] A focus on secondary progressive multiple sclerosis (SPMS): challenges in diagnosis and definition
    Inojosa, Hernan
    Proschmann, Undine
    Akguen, Katja
    Ziemssen, Tjalf
    [J]. JOURNAL OF NEUROLOGY, 2021, 268 (04) : 1210 - 1221
  • [5] A focus on secondary progressive multiple sclerosis (SPMS): challenges in diagnosis and definition
    Hernan Inojosa
    Undine Proschmann
    Katja Akgün
    Tjalf Ziemssen
    [J]. Journal of Neurology, 2021, 268 : 1210 - 1221
  • [6] Natalizumab in secondary progressive multiple sclerosis
    Edan, Gilles
    [J]. LANCET NEUROLOGY, 2018, 17 (05): : 384 - 385
  • [7] Defining secondary progressive multiple sclerosis
    Lorscheider, J.
    Buzzard, K.
    Jokubaitis, V.
    Spelman, T.
    Havrdova, E.
    Horakova, D.
    Trojano, M.
    Izquierdo, G.
    Girard, M.
    Duquette, P.
    Prat, A.
    Lugaresi, A.
    Grand'Maison, F.
    Grammond, P.
    Hupperts, R.
    Alroughani, R.
    Sola, P.
    Boz, C.
    Terzi, M.
    Pucci, E.
    Lechner-Scott, J.
    Bergamaschi, R.
    Oreja-Guevara, C.
    Iuliano, G.
    Van Pesch, V.
    Bolanos, R. Fernandez
    Granella, F.
    Rio, M. E.
    Ramo, C.
    Spitaleri, D. L.
    Petersen, T.
    Slee, M.
    Verheul, F.
    Ampapa, R.
    Amato, M. P.
    McCombe, P.
    Vucic, S.
    Sanchez Menoyo, J. L.
    Cristiano, E.
    Barnett, M.
    Hodgkinson, S.
    Cabrera-Gomez, J. A.
    Olascoaga, J.
    Saladino, M. L.
    Flechter, S.
    Gray, O.
    Deri, N.
    Butzkueven, H.
    Kalincik, T.
    [J]. MULTIPLE SCLEROSIS JOURNAL, 2015, 21 : 798 - 800
  • [8] Siponimod in secondary progressive multiple sclerosis
    Rissardo, Jamir Pitton
    Caprara, Ana Leticia Fornari
    [J]. INTERNATIONAL ARCHIVES OF HEALTH SCIENCES, 2020, 7 (03) : 155 - 155
  • [9] Defining secondary progressive multiple sclerosis
    Lorscheider, Johannes
    Buzzard, Katherine
    Jokubaitis, Vilija
    Spelman, Tim
    Lechner-Scott, Jeannette
    McCombe, Pam
    Vucic, Steve
    Barnett, Michael
    Butzkueven, Helmut
    Kalincik, Tomas
    [J]. MULTIPLE SCLEROSIS JOURNAL, 2015, 21 (14) : NP15 - NP15
  • [10] Primary and secondary progressive multiple sclerosis
    Vukusic, S
    Confavreux, C
    [J]. JOURNAL OF THE NEUROLOGICAL SCIENCES, 2003, 206 (02) : 153 - 155
12345