In Vivo Function of the ER-Golgi Transport Protein LMAN1 in Photoreceptor Homeostasis

被引：3
|
作者：
Hao, Hong [1 ]
Gregorski, Janina [2 ]
Qian, Haohua [3 ]
Li, Yichao [3 ]
Gao, Chun Y. [4 ]
Idrees, Sana [5 ]
Zhang, Bin [6 ]
机构：
[1] NEI, Neurobiol Neurodegenerat & Repair Lab, NIH, Bethesda, MD 20892 USA
[2] New York Med Coll, Grad Sch Basic Med Sci, Valhalla, NY 10595 USA
[3] NEI, Visual Funct Core, Bethesda, MD 20892 USA
[4] NEI, Biol Imaging Core Facil, Bethesda, MD 20892 USA
[5] George Washington Univ, Sch Med, Washington, DC 20037 USA
[6] Cleveland Clin Fdn, Lerner Res Inst, Genom Med Inst, Cleveland, OH 44195 USA
来源：
RETINAL DEGENERATIVE DISEASES: MECHANISMS AND EXPERIMENTAL THERAPY | 2014年 / 801卷
关键词：
LMAN1; NRL; Photoreceptor; Transport; Homeostasis; COMPLEX; GM130;
D O I：
10.1007/978-1-4614-3209-8_50
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
LMAN1 is a type I transmembrane protein that selectively transports its cargo proteins from ER to ER-Golgi intermediate compartment (ERGIC) and Golgi. Lman1 is a direct target of the transcription factor NRL in mouse retina. Therefore, we examined the in vivo function of LMAN1 in retina. Although Lman1(-/-) mouse eyes did not show abnormality in histology and electroretinogram analysis at 3 months, Lman1(-/-) retina at 6 months showed a decrease in cis-Golgi markers GM130 and GRASP65. We also observed abnormal level and location of Rhodopsin in these mice. Taken together, LMAN1 may play a role in photoreceptor gene transport and homeostasis.
引用
收藏
页码：395 / 399
页数：5
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