In Vivo Function of the ER-Golgi Transport Protein LMAN1 in Photoreceptor Homeostasis

被引：3

作者：

Hao, Hong ^{[1
]}

Gregorski, Janina ^{[2
]}

Qian, Haohua ^{[3
]}

Li, Yichao ^{[3
]}

Gao, Chun Y. ^{[4
]}

Idrees, Sana ^{[5
]}

Zhang, Bin ^{[6
]}

机构：

[1] NEI, Neurobiol Neurodegenerat & Repair Lab, NIH, Bethesda, MD 20892 USA

[2] New York Med Coll, Grad Sch Basic Med Sci, Valhalla, NY 10595 USA

[3] NEI, Visual Funct Core, Bethesda, MD 20892 USA

[4] NEI, Biol Imaging Core Facil, Bethesda, MD 20892 USA

[5] George Washington Univ, Sch Med, Washington, DC 20037 USA

[6] Cleveland Clin Fdn, Lerner Res Inst, Genom Med Inst, Cleveland, OH 44195 USA

来源：

RETINAL DEGENERATIVE DISEASES: MECHANISMS AND EXPERIMENTAL THERAPY | 2014年 / 801卷

关键词：

LMAN1; NRL; Photoreceptor; Transport; Homeostasis; COMPLEX; GM130;

D O I：

10.1007/978-1-4614-3209-8_50

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

LMAN1 is a type I transmembrane protein that selectively transports its cargo proteins from ER to ER-Golgi intermediate compartment (ERGIC) and Golgi. Lman1 is a direct target of the transcription factor NRL in mouse retina. Therefore, we examined the in vivo function of LMAN1 in retina. Although Lman1(-/-) mouse eyes did not show abnormality in histology and electroretinogram analysis at 3 months, Lman1(-/-) retina at 6 months showed a decrease in cis-Golgi markers GM130 and GRASP65. We also observed abnormal level and location of Rhodopsin in these mice. Taken together, LMAN1 may play a role in photoreceptor gene transport and homeostasis.

引用

页码：395 / 399

页数：5

共 50 条

[1] The imaging of ER-Golgi and intra-Golgi protein transport
Kurokawa, Kazuo
[J]. GENES & GENETIC SYSTEMS, 2016, 91 (06) : 327 - 327
[2] Molecular basis of LMAN1 in coordinating LMAN1-MCFD2 cargo receptor formation and ER-to-Golgi transport of FV/FVIII
Zheng, Chunlei
Liu, Hui-Hui
Yuan, Shuguang
Zhou, Jiahai
Zhang, Bin
[J]. BLOOD, 2010, 116 (25) : 5698 - 5706
[3] LMAN1-MCFD2 complex is a cargo receptor for the ER-Golgi transport of α1-antitrypsin
Zhang, Yuan
Zhu, Min
Zheng, Chunlei
Wei, Wei
Emmer, Brian T.
Zhang, Bin
[J]. BIOCHEMICAL JOURNAL, 2022, 479 (07) : 839 - 855
[4] Characterization of retrograde ER-Golgi transport
Colanzi, A
Cericola, C
Polishchuk, RS
Mironov, AA
Fusella, A
Mironov, AA
Luini, A
[J]. MOLECULAR BIOLOGY OF THE CELL, 1997, 8 : 2364 - 2364
[5] ER-Golgi transport: authors' response
Brandizzi, Federica
Barlowe, Charles
[J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2014, 15 (03) : 1 - 1
[6] ER-Golgi transport: authors' response
Federica Brandizzi
Charles Barlowe
[J]. Nature Reviews Molecular Cell Biology, 2014, 15 : 1 - 1
[7] Separate roles of LMAN1 and MCFD2 in ER-to-Golgi trafficking of FV and FVIII
Zhang, Yuan
Liu, Zhigang
Zhang, Bin
[J]. BLOOD ADVANCES, 2023, 7 (07) : 1286 - 1296
[8] Protein sorting at the ER-Golgi interface
Gomez-Navarro, Natalia
Miller, Elizabeth
[J]. JOURNAL OF CELL BIOLOGY, 2016, 215 (06): : 769 - 778
[9] p115 function an ER-Golgi transport is independent of phosphorylation
Brandon, E
Gao, Y
Garcia-Mata, R
Sztul, E
[J]. MOLECULAR BIOLOGY OF THE CELL, 2002, 13 : 356A - 356A
[10] Direct identification of the ER-golgi carriers in vivo
Mironov, A
Mironov, A
Deerinck, T
Polishchuk, R
Luini, A
Ellisman, M
Negri, M
[J]. MOLECULAR BIOLOGY OF THE CELL, 1999, 10 : 212A - 212A

← 1 2 3 4 5 →