Insulin resistance, hepatic lipid and adipose tissue distribution in HIV-infected men
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作者:
He, Qing
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Columbia Univ, St Lukes Roosevelt Hosp Ctr, Dept Med, Div Gastroenterol, New York, NY 10027 USAColumbia Univ, St Lukes Roosevelt Hosp Ctr, Dept Med, Div Gastroenterol, New York, NY 10027 USA
He, Qing
[1
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Engelson, Ellen S.
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Columbia Univ, St Lukes Roosevelt Hosp Ctr, Dept Med, Div Gastroenterol, New York, NY 10027 USAColumbia Univ, St Lukes Roosevelt Hosp Ctr, Dept Med, Div Gastroenterol, New York, NY 10027 USA
Engelson, Ellen S.
[1
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Ionescu, Gabriel
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Columbia Univ, St Lukes Roosevelt Hosp Ctr, Dept Med, Div Gastroenterol, New York, NY 10027 USAColumbia Univ, St Lukes Roosevelt Hosp Ctr, Dept Med, Div Gastroenterol, New York, NY 10027 USA
Ionescu, Gabriel
[1
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Glesby, Marshall J.
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机构:
New York Presbyterian Hosp, Weill Cornell Med Coll, Dept Med, Div Int Med & Infect Dis, New York, NY USAColumbia Univ, St Lukes Roosevelt Hosp Ctr, Dept Med, Div Gastroenterol, New York, NY 10027 USA
Glesby, Marshall J.
[2
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Albu, Jeanine B.
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Columbia Univ, St Lukes Roosevelt Hosp Ctr, Dept Med, Div Endocrinol & Metab, New York, NY USAColumbia Univ, St Lukes Roosevelt Hosp Ctr, Dept Med, Div Gastroenterol, New York, NY 10027 USA
Albu, Jeanine B.
[3
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Kotler, Donald P.
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Columbia Univ, St Lukes Roosevelt Hosp Ctr, Dept Med, Div Gastroenterol, New York, NY 10027 USAColumbia Univ, St Lukes Roosevelt Hosp Ctr, Dept Med, Div Gastroenterol, New York, NY 10027 USA
Kotler, Donald P.
[1
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机构:
[1] Columbia Univ, St Lukes Roosevelt Hosp Ctr, Dept Med, Div Gastroenterol, New York, NY 10027 USA
[2] New York Presbyterian Hosp, Weill Cornell Med Coll, Dept Med, Div Int Med & Infect Dis, New York, NY USA
[3] Columbia Univ, St Lukes Roosevelt Hosp Ctr, Dept Med, Div Endocrinol & Metab, New York, NY USA
Background: A large proportion of HIV-infected patients on antiretroviral medication develop insulin resistance, especially in the context of fat redistribution. This study investigates the interrelationships among fat distribution, hepatic lipid content, and insulin resistance in HIV-infected men. Methods: We performed a cross-sectional analysis of baseline data from 23 HIV-infected participants in three prospective clinical studies. Magnetic resonance spectroscopy was used to quantify hepatic lipid concentrations. Magnetic resonance imaging was used to quantify whole-body adipose tissue compartments: that is, subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) volumes, as well as the intermuscular adipose tissue (IMAT) subcompartment and the omental-mesenteric adipose tissue (OMAT) and retroperitoneal adipose tissue (RPAT) subcompartments of VAT. The homeostasis model for assessment of insulin resistance (HOMA-IR) was calculated from fasting glucose and insulin concentrations. Results: Hepatic lipid content correlated significantly with total VAT (r=0.62, P=0.0014), but not with SAT (r=0.053, P=0.81). In univariate analysis, hepatic lipid content was associated with the OMAT (r=0.67, P=0.0004) and RPAT (r=0.53, P=0.009) subcompartments; HOMA-IR correlated with both VAT and hepatic lipid contents (r=0.61, P=0.057 and r=0.68, P=0.0012, respectively). In stepwise linear regression models, hepatic lipid had the strongest associations with OMAT and with HOMA-IR. Conclusion: Hepatic lipid content is associated with VAT volume, especially the OMAT subcompartment, in HIV-infected men. Hepatic lipid content is associated with insulin resistance in HIV-infected men. Hepatic lipid content might mediate the relationship between VAT and insulin resistance among treated, HIV-infected men.
机构:
Univ Colorado, Div Infect Dis & Geriatr Med, Dept Med, Aurora, CO USAUniv Colorado, Div Infect Dis & Geriatr Med, Dept Med, Aurora, CO USA
Erlandson, Kristine M.
Jiang, Ying
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Case Western Reserve Univ, Dept Epidemiol & Biostat, Cleveland, OH 44106 USAUniv Colorado, Div Infect Dis & Geriatr Med, Dept Med, Aurora, CO USA
Jiang, Ying
Debanne, Sara M.
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Case Western Reserve Univ, Dept Epidemiol & Biostat, Cleveland, OH 44106 USAUniv Colorado, Div Infect Dis & Geriatr Med, Dept Med, Aurora, CO USA
Debanne, Sara M.
McComsey, Grace A.
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机构:
Case Western Reserve Univ, Div Pediat Infect Dis & Rheumatol, Dept Med & Pediat, Cleveland, OH 44106 USAUniv Colorado, Div Infect Dis & Geriatr Med, Dept Med, Aurora, CO USA
机构:
Univ Miami, Miller Sch Med, Dept Pediat, Miami, FL 33136 USAUniv Texas Tyler, Dept Pharmaceut Sci, Ben & Maytee Fisch Coll Pharm, Tyler, TX 75799 USA
Miller, Tracie L.
Wang, Jiajia
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机构:
Harvard TH Chan Sch Publ Hlth, Ctr Biostat AIDS Res, Boston, MA USAUniv Texas Tyler, Dept Pharmaceut Sci, Ben & Maytee Fisch Coll Pharm, Tyler, TX 75799 USA
Wang, Jiajia
Jacobson, Denise L.
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机构:
Harvard TH Chan Sch Publ Hlth, Ctr Biostat AIDS Res, Boston, MA USAUniv Texas Tyler, Dept Pharmaceut Sci, Ben & Maytee Fisch Coll Pharm, Tyler, TX 75799 USA
Jacobson, Denise L.
Geffner, Mitchell E.
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机构:
Childrens Hosp Los Angeles, Saban Res Inst, Los Angeles, CA 90027 USAUniv Texas Tyler, Dept Pharmaceut Sci, Ben & Maytee Fisch Coll Pharm, Tyler, TX 75799 USA
Geffner, Mitchell E.
Van Dyke, Russell B.
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机构:
Tulane Univ, Sch Med, 1430 Tulane Ave, New Orleans, LA 70112 USAUniv Texas Tyler, Dept Pharmaceut Sci, Ben & Maytee Fisch Coll Pharm, Tyler, TX 75799 USA
Van Dyke, Russell B.
Gerschenson, Mariana
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Univ Hawaii, John A Burns Sch Med, Dept Cell & Mol Biol, 651 Ilalo St BSB 222B, Honolulu, HI 96813 USAUniv Texas Tyler, Dept Pharmaceut Sci, Ben & Maytee Fisch Coll Pharm, Tyler, TX 75799 USA
机构:
Univ Massachusetts, Sch Med, Howard Hughes Med Inst, Worcester, MA 01605 USA
Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USAUniv Massachusetts, Sch Med, Howard Hughes Med Inst, Worcester, MA 01605 USA
Sabio, Guadalupe
Das, Madhumita
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机构:
Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USAUniv Massachusetts, Sch Med, Howard Hughes Med Inst, Worcester, MA 01605 USA
Das, Madhumita
Mora, Alfonso
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机构:
Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USAUniv Massachusetts, Sch Med, Howard Hughes Med Inst, Worcester, MA 01605 USA
Mora, Alfonso
Zhang, Zhiyou
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机构:Univ Massachusetts, Sch Med, Howard Hughes Med Inst, Worcester, MA 01605 USA
Zhang, Zhiyou
Jun, John Y.
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机构:
Penn State Univ, Coll Med, Dept Med, Hershey, PA 17033 USAUniv Massachusetts, Sch Med, Howard Hughes Med Inst, Worcester, MA 01605 USA
Jun, John Y.
Ko, Hwi Jin
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机构:Univ Massachusetts, Sch Med, Howard Hughes Med Inst, Worcester, MA 01605 USA
Ko, Hwi Jin
Barrett, Tamera
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机构:
Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USAUniv Massachusetts, Sch Med, Howard Hughes Med Inst, Worcester, MA 01605 USA
Barrett, Tamera
Kim, Jason K.
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机构:Univ Massachusetts, Sch Med, Howard Hughes Med Inst, Worcester, MA 01605 USA
Kim, Jason K.
Davis, Roger J.
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机构:
Univ Massachusetts, Sch Med, Howard Hughes Med Inst, Worcester, MA 01605 USA
Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USAUniv Massachusetts, Sch Med, Howard Hughes Med Inst, Worcester, MA 01605 USA
机构:
St Petersburg State Univ, Dept Psychiat & Addict, St Petersburg, Russia
St Petersburg Psychiat Hosp, Outpatient Dept 2, St Petersburg, RussiaSt Petersburg State Univ, Dept Psychiat & Addict, St Petersburg, Russia
Ashenbrenner, Y.
Chumakov, E.
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机构:
St Petersburg State Univ, Dept Psychiat & Addict, St Petersburg, Russia
St Petersburg Psychiat Hosp, Outpatient Dept 2, St Petersburg, RussiaSt Petersburg State Univ, Dept Psychiat & Addict, St Petersburg, Russia
Chumakov, E.
Petrova, N.
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机构:
St Petersburg State Univ, Dept Psychiat & Addict, St Petersburg, RussiaSt Petersburg State Univ, Dept Psychiat & Addict, St Petersburg, Russia