Organocatalytic 1,3-dipolar [3+3] cycloaddition reaction of 1,2-cyclohexanedione with azides: direct access to highly substituted 1,2,3-triazoles

被引：14
|
作者：
Xu, Xianhong [1 ]
Shi, Zhenyan [1 ]
Li, Wenjun [1 ]
机构：
[1] Qingdao Univ, Sch Pharm, Qingdao 266021, Peoples R China
来源：
NEW JOURNAL OF CHEMISTRY | 2016年 / 40卷 / 08期
基金：
中国国家自然科学基金;
关键词：
METAL-FREE SYNTHESIS; HIGH-YIELDING SYNTHESIS; ONE-POT STRATEGY; REGIOSELECTIVE SYNTHESIS; REGIOSPECIFIC SYNTHESIS; N-TOSYLHYDRAZONES; CLICK REACTION; 1,4-DISUBSTITUTED 1,2,3-TRIAZOLES; ALKYNE CYCLOADDITION; TRIAZOLE FORMATION;
D O I：
10.1039/c6nj01083k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Enamine-mediated 1,3-dipolar [3+3] cycloaddition reactions of 1,2-cyclohexanedione with azides have been developed. This strategy could generate highly substituted 1,2,3-triazoles in high yields and high levels of regioselectivities. It has been demonstrated that various types of products could be obtained using different organocatalysts and substrates.
引用
收藏
页码：6559 / 6563
页数：5
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