Solid-phase synthesis of 1,2,3-triazoles via 1,3-dipolar cycloaddition

被引：70
|
作者：
Harju, K
Vahermo, M
Mutikainen, I
Yli-Kauhaluoma, J
机构：
[1] Univ Helsinki, Dept Pharm, Viikki Drug Discovery Technol Ctr, FIN-00014 Helsinki, Finland
[2] Univ Helsinki, Dept Chem, Inorgan Chem Lab, FIN-00014 Helsinki, Finland
来源：
JOURNAL OF COMBINATORIAL CHEMISTRY | 2003年 / 5卷 / 06期
关键词：
D O I：
10.1021/cc030110c
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The solid-phase synthesis of 1,2,3-triazoles via 1,3-dipolar cycloaddition of polymer-bound azides to various alkynes is reported. Polymer-bound azides were synthesized from polymer-bound halides and sodium azide and reacted with alkynes to produce polymer-bound 1,2,3-triazoles. Cleavage of the triazoles was performed with trifluoroacetic acid. A traceless synthesis of 1,2,3-triazoles was developed using 2-methoxy-substituted resin (polymer-bound 4-hydroxy-2-methoxybenzyl alcohol). In addition, a synthesis of 4-hydroxybenzyl-substituted 1,2,3-triazoles from the bromo-Wang resin (4-(bromomethyl)phenoxymethyl polystyrene) was achieved.
引用
收藏
页码：826 / 833
页数：8
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