First and second generations of COX-2 selective inhibitors

被引：1
|
作者：
de Leval, X
Julémont, F
Benoit, V
Frederich, M
Pirotte, B
Dogné, JM
机构：
[1] Univ Liege, Nat & Synth Drugs Res Ctr, Dept Med Chem, Med Chem Lab, B-4000 Liege, Belgium
[2] Univ Liege, Cellular & Moll Therapeut Ctr, B-4000 Liege, Belgium
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2004年 / 4卷 / 06期
关键词：
COX-2; inhibitors; selectivity; pre-clinical data;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The identification and characterization of the inducible form of cyclooxygenases (COX-2) stimulated the investigations to develop efficient, non-steroidal anti-inflammatory drugs (NSAIDs) with reduced side effects (essentially gastro-intestinal toxicity) compared to classical NSAIDs. This review focuses on the chemical and pharmacological properties (pre-clinical data) of marketed COX-2 inhibitors.
引用
收藏
页码：597 / 601
页数：5
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