Cancers take their Toll - the function and regulation of Toll-like receptors in cancer cells

被引：170

作者：

Chen, R. ^{[2
]}

Alvero, A. B. ^{[1
]}

Silasi, D-A ^{[1
]}

Steffensen, K. D. ^{[3
]}

Mor, G. ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Obstet Gynecol & Reprod Sci, Reprod Immunol Unit, New Haven, CT 06520 USA

[2] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT USA

[3] Vejle Hosp, Dept Oncol, Vejle, Denmark

来源：

ONCOGENE | 2008年 / 27卷 / 02期

关键词：

ovarian cancer; Toll-like receptors; MyD88; inflammation; tissue repair; chemoresistance;

D O I：

10.1038/sj.onc.1210907

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cancer could be deemed as an abnormal and uncontrolled tissue repair process. Therefore, it would not be surprising that factors that function in the tissue repair process, such as cytokines, chemokines, growth factors and Toll-like receptor (TLR) ligands, as well as growth signals for compensatory proliferation, would also be key factors in regulating and enhancing cancer progression. The TLR pathways, which play a critical role in tissue repair, are also key regulators in cancer progression as well as chemoresistance. TLRs serve as cell surface sensors that can initiate pathways leading to proliferation and chemoresistance; as well as mediators that are able to regulate the infiltrating immune cells to provide further support for cancer progression.

引用

页码：225 / 233

页数：9

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