Methylenetetrahydrofolate Reductase Polymorphisms and Risk of Recurrent Pregnancy Loss: a Case-Control Study

被引:19
|
作者
Hwang, Kyu Ri [1 ,2 ]
Choi, Young Min [1 ,3 ]
Kim, Jin Ju [1 ,4 ]
Lee, Sung Ki [5 ]
Yang, Kwang Moon [6 ,7 ]
Paik, Eun Chan [8 ]
Jeong, Hyeon Jeong [9 ]
Jun, Jong Kwan [1 ]
Yoon, Sang Ho [10 ]
Hong, Min A. [3 ]
机构
[1] Seoul Natl Univ, Coll Med, Dept Obstet & Gynecol, 103 Daehak Ro, Seoul 03080, South Korea
[2] Seoul Natl Univ, Boramae Med Ctr, Seoul Metropolitan Govt, Dept Obstet & Gynecol, Seoul, South Korea
[3] Seoul Natl Univ, Coll Med, Med Res Ctr, Inst Reprod Med & Populat, Seoul, South Korea
[4] Seoul Natl Univ Hosp, Healthcare Syst Gangnam Ctr, Dept Obstet & Gynecol, Seoul, South Korea
[5] Konyang Univ, Coll Med, Dept Obstet & Gynecol, Daejeon, South Korea
[6] Dankook Univ, Coll Med, Cheil Gen Hosp, Dept Obstet & Gynecol, Seoul, South Korea
[7] Dankook Univ, Coll Med, Womens Healthcare Ctr, Seoul, South Korea
[8] Bundang Cheil Womens Hosp, Dept Obstet & Gynecol, Sungnam, South Korea
[9] Seoul Rachel Fertil Ctr, Dept Obstet & Gynecol, Seoul, South Korea
[10] Dongguk Univ, Grad Sch Med, Dept Obstet & Gynecol, Seoul, South Korea
关键词
MTHFR Gene; Recurrent Pregnancy Loss; Single-Nucleotide Polymorphisms; Korean; THROMBOPHILIC GENE-MUTATIONS; MTHFR C677T POLYMORPHISM; SPONTANEOUS-ABORTION; A1298C POLYMORPHISM; INDIAN POPULATION; CERVICAL-CANCER; COMMON MUTATION; METAANALYSIS; WOMEN; HOMOCYSTEINE;
D O I
10.3346/jkms.2017.32.12.2029
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The balance between coagulation and fibrinolysis is an essential part in early pregnancy. Mutations in methylenetetrahydrofolate reductase (MTHFR) gene lead to decreased activity of the enzyme and hyperhomocysteinemia, which then induces platelet aggregation by promoting endothelial oxidative damage, possibly resulting in adverse effect on maintenance of pregnancy. We investigated the role of MTHFR single nucleotide polymorphisms (SNPs), C677T and A1298C, in Korean patients with recurrent pregnancy loss (RPL). We conducted a prospective case-control study in the Korean population. Subjects included 302 women with 2 or more consecutive, unexplained, spontaneous miscarriages before 20 weeks of gestation and 315 control women without a history of recurrent miscarriages. The genotyping for C677T and A1298C polymorphisms was performed using the TaqMan assay. Continuous variables were compared using Student's t-test, and chi(2) test was used to evaluate differences in the genotype distributions between the RPL and the controls. The genotype distribution of both polymorphisms in the RPL group did not differ from those of the controls. For further analysis, if RPL patients were divided according to the numbers of pregnancy losses (>= 2 and >= 3) neither group was significantly different compared with controls. MTHFR gene C677T and A1298C polymorphisms are not associated with idiopathic RPL in Korean women, suggesting that those may not be susceptible allelic variants or be deficient to cause RPL.
引用
收藏
页码:2029 / 2034
页数:6
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