Vitamin D in the Prevention and Treatment of Diabetic Neuropathy

被引：28

作者：

Putz, Zsuzsanna ^{[1
]}

Tordai, Dora ^{[1
]}

Hajdu, Noemi ^{[1
]}

Vagi, Orsolya Erzsebet ^{[1
]}

Kempler, Miklos ^{[2
]}

Bekeffy, Magdolna ^{[1
]}

Korei, Anna Erzsebet ^{[1
]}

Istenes, Ildiko ^{[1
]}

Horvath, Viktor ^{[1
]}

Stoian, Anca Pantea ^{[3
]}

Rizzo, Manfredi ^{[3
,4
,5
]}

Papanas, Nikolaos ^{[6
]}

Kempler, Peter ^{[1
]}

机构：

[1] Semmelweis Univ, Dept Internal Med & Oncol, Koranyi S U 2-a, H-1083 Budapest, Hungary

[2] Semmelweis Univ, Dept Internal Med & Hematol, Budapest, Hungary

[3] Carol Davila Univ, Dept Diabet Nutr & Metab Dis, Bucharest, Romania

[4] Univ Palermo, Biomed Dept Internal Med & Med Specialties, Palermo, Italy

[5] Univ South Carolina, Div Endocrinol Diabet & Metab, Sch Med, Columbia, SC 29208 USA

[6] Democritus Univ Thrace, Dept Internal Med 2, Komotini, Greece

来源：

CLINICAL THERAPEUTICS | 2022年 / 44卷 / 05期

关键词：

cardiovascular autonomic neuropathy; sensory neuropathy; vitamin D; CARDIOVASCULAR AUTONOMIC NEUROPATHY; PERIPHERAL NEUROPATHY; D DEFICIENCY; GROWTH-FACTOR; FOOT ULCER; ASSOCIATION; LEVEL; RISK;

D O I：

10.1016/j.clinthera.2022.03.012

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Purpose: Neuropathy is one of the most important complications of diabetes. According to recent advances, vitamin D deficiency might play a role in the development and progression of diabetic neuropathy. Moreover, therapeutic vitamin D supplementation has the potential to improve this condition. The aim of the present review was to summarize new data available in this area. Methods: The PubMed database was searched for articles written in English and published through September 2021, using combinations of the following key words: vitamin D, diabetes, diabetes mellitus, diabetic neuropathy, polyneuropathy, peripheral neuropathy, cardiac autonomic neuropathy, supplementation, and therapy. Findings: A number of studies have suggested that vitamin D deficiency can play a significant role in the development of peripheral neuropathy, diabetic foot ulcers, as well as cardiovascular autonomic neuropathy in patients with type 2 diabetes. Vitamin D supplementation might serve as an effective adjuvant therapy for neuropathic pain and may slow or stop the progression of neural damage. (C) 2022 The Author(s). Published by Elsevier Inc.

引用

页码：813 / 823

页数：11

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