Factors influencing sib risks for multiple sclerosis

被引：27
|
作者：
Sadovnick, AD
Yee, IML
Ebers, GC
机构：
[1] Univ British Columbia, Dept Med Genet, Vancouver, BC, Canada
[2] Univ Oxford, Dept Clin Neurol, Oxford, England
来源：
CLINICAL GENETICS | 2000年 / 58卷 / 06期
关键词：
age of onset; genetic loading; multiple sclerosis; sib risks;
D O I：
10.1034/j.1399-0004.2000.580602.x
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Multiple sclerosis (MS) is now thought to be a complex trait determined by genetic and non-genetic (environmental) factors. The study group, identified from the Canadian Collaborative Project on Genetic Susceptibility to MS, consisted of 1083 MS index cases, 2166 of their parents and 3112 of their sibs. The results, together with those of a previous study on an independent data set, suggest that gender, age of MS onset and having one parent with MS may individually and interactively alter sib risks for MS. These data are important for genetic counselling and for molecular genetic (genome screens, candidate gene analyses) studies.
引用
收藏
页码：431 / 435
页数：5
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