Full genomic analysis of G1P[8] rotavirus strains recovered from rotavirus vaccinated and non-vaccinated children hospitalized for acute gastroenteritis in Pune, western India

被引：6
|
作者：
Pradhan, Gauri N. [1 ]
Chitambar, Shobha D. [1 ]
机构：
[1] Natl Inst Virol, 20-A,Dr Ambedkar Rd,Post Box 11, Pune 411001, Maharashtra, India
来源：
JOURNAL OF MEDICAL VIROLOGY | 2018年 / 90卷 / 04期
关键词：
antigenic variation; G1P[8; human rotavirus; rotarix; vaccines; vaccine strains; HUMAN WA-LIKE; SEQUENCE-ANALYSIS; DIVERSITY; REVEALS; TRENDS; IMPACT;
D O I：
10.1002/jmv.25007
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
G1P[8] rotaviruses are predominant in causing diarrheal infections in humans all over the world. This study reports the analysis of complete genomes of G1P[8] strains, two each recovered from Rotarix vaccine recipients and non-recipients hospitalized for acute gastroenteritis in Pune, western India. All four strains showed a genogroup-1 backbone with intra-genotypic diversity in the VP7 and VP4 gene segments and a homogeneous constellation of the internal gene segments. A divergence in the range of 1.4-17.3% from Rotarix vaccine strain was revealed by structural and non-structural genes of the strains at nucleotide and amino acid level. These data reflect ability of such G1P[8] strains to cause rotavirus infections in humans.
引用
收藏
页码：772 / 778
页数：7
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