Influence of rapid COVID-19 vaccine development on vaccine hesitancy

Introduction: In the race to deploy vaccines to prevent COVID-19, there is a need to understand factors influencing vaccine hesitancy. Secondary risk theory is a useful framework to explain this, accounting for concerns about vaccine efficacy and safety. Methods: During the first week of July, 2020, participants (N = 216) evaluated one of three different hypothetical vaccine scenarios describing an FDA-approved vaccine becoming available "next week," "in one year," or "in two years." Dependent variables were perceived vaccine efficacy, self-efficacy, perceived vaccine risk, and vaccination willingness. Covariates included vaccine conspiracy beliefs, science pessimism, media dependency, and perceived COVID-19 risk. Data analysis employed multiple analysis of covariance (MANCOVA). Results: Perceived vaccine efficacy was lowest for the next-week vaccine (eta 2p = .045). Self-efficacy was higher for the two-year vaccine than the next-week vaccine (eta 2p = .029). Perceived vaccine risk was higher for the next-week vaccine than for the one-year vaccine (eta 2p = .032). Vaccination willingness did not differ among experimental treatments. In addition, vaccine conspiracy beliefs were negatively related to perceived vaccine efficacy (eta 2p = .142), self-efficacy (eta 2p = .031), and vaccination willingness (eta 2p = .143) and positively related to perceived vaccine risk (eta 2p = .216). Conclusions: The rapid development of the COVID-19 vaccine may have heightened public concerns over efficacy, availability, and safety. However, the current findings showed a general willingness to take even the most rapidly developed vaccine. Nonetheless, there remains a need to communicate publicly and transparently about vaccine efficacy and safety and work to reduce vaccine conspiracy beliefs. (c) 2021 Elsevier Ltd. All rights reserved.