A facile solid phase synthesis of tetramic acid

被引：20
|
作者：
Liu, ZX [1 ]
Ruan, XX [1 ]
Huang, X [1 ]
机构：
[1] Zhejiang Univ, Dept Chem, Hangzhou 310028, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 15期
关键词：
D O I：
10.1016/S0960-894X(03)00502-X
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The condensation of N-acylated amino acids with polymer-supported cyclic malonic acid ester was carried out in the presence of DCC/DMAP. The cyclisation of the intermediate resin, by heating in an organic solvent, gave the N-protected tetramic acid derivatives in good yields and high purity. (C) 2003 Elsevier Ltd. All rights reserved.
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页码：2505 / 2507
页数：3
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