Measurements of the effect of membrane asymmetry on the mechanical properties of lipid bilayers

被引：86

作者：

Elani, Yuval ^{[1
]}

Purushothaman, Sowmya ^{[1
]}

Booth, Paula J. ^{[2
]}

Seddon, John M. ^{[1
]}

Brooks, Nicholas J. ^{[1
]}

Law, Robert V. ^{[1
]}

Ces, Oscar ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AZ, England

[2] Kings Coll London, Dept Chem, London SE1 1DB, England

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 32期

基金：

英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

CTP-PHOSPHOCHOLINE CYTIDYLYLTRANSFERASE; GIANT UNILAMELLAR VESICLES; BENDING RIGIDITY; SPONTANEOUS CURVATURE; ARTIFICIAL CELL; IN-VITRO; PROTEIN; CHANNEL; MODULATION; FLIPPASES;

D O I：

10.1039/c5cc00712g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We detail an approach for constructing asymmetric membranes and characterising their mechanical properties, leading to the first measurement of the effect of asymmetry on lipid bilayer mechanics. Our results demonstrate that asymmetry induces a significant increase in rigidity compared to symmetric membranes. Given that all biological membranes are asymmetric our findings have profound implications for the role of this phenomenon in biology.

引用

页码：6976 / 6979

页数：4

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