Plasma netrin-1 is a diagnostic biomarker of human cancers

被引：58

作者：

Ramesh, Ganesan ^{[1
]}

Berg, Arthur ^{[2
]}

Jayakumar, Calpurnia ^{[2
]}

机构：

[1] Med Coll Georgia, Vasc Biol Ctr, Dept Med, Augusta, GA 30912 USA

[2] Penn State Univ, Coll Med, Dept Publ Hlth Sci, Hershey, PA 17033 USA

来源：

BIOMARKERS | 2011年 / 16卷 / 02期

关键词：

SURVIVAL FACTOR; RECEPTORS; ANGIOGENESIS; MIGRATION; EXPRESSION; ALPHA-6-BETA-4; PROGRESSION; KIDNEY; INJURY; ACTS;

D O I：

10.3109/1354750X.2010.541564

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Objectives: aEuro,To determine whether plasma netrin-1 can be used as a diagnostic biomarker of human cancer. Materials and Methods: aEuro,A total of 300 cancer plasma samples from breast, renal, prostate, liver, meningioma, pituitary adenoma, glioblastoma, lung, pancreatic and colon cancer patients were compared against 138 control plasma samples. Netrin-1 levels were quantified by ELISA and immunohistochemistry. Results: aEuro,Plasma netrin-1 levels were significantly increased in breast, renal, prostate, liver, meningioma, pituitary adenoma, and glioblastoma cancers as compared to control samples. Discussion and Conclusion: aEuro,Our results suggest that plasma netrin-1 can be used as a diagnostic biomarker for many human cancers.

引用

页码：172 / 180

页数：9

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