Plasma netrin-1 is a diagnostic biomarker of human cancers

被引：58
|
作者：
Ramesh, Ganesan [1 ]
Berg, Arthur [2 ]
Jayakumar, Calpurnia [2 ]
机构：
[1] Med Coll Georgia, Vasc Biol Ctr, Dept Med, Augusta, GA 30912 USA
[2] Penn State Univ, Coll Med, Dept Publ Hlth Sci, Hershey, PA 17033 USA
来源：
BIOMARKERS | 2011年 / 16卷 / 02期
关键词：
SURVIVAL FACTOR; RECEPTORS; ANGIOGENESIS; MIGRATION; EXPRESSION; ALPHA-6-BETA-4; PROGRESSION; KIDNEY; INJURY; ACTS;
D O I：
10.3109/1354750X.2010.541564
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Objectives: aEuro,To determine whether plasma netrin-1 can be used as a diagnostic biomarker of human cancer. Materials and Methods: aEuro,A total of 300 cancer plasma samples from breast, renal, prostate, liver, meningioma, pituitary adenoma, glioblastoma, lung, pancreatic and colon cancer patients were compared against 138 control plasma samples. Netrin-1 levels were quantified by ELISA and immunohistochemistry. Results: aEuro,Plasma netrin-1 levels were significantly increased in breast, renal, prostate, liver, meningioma, pituitary adenoma, and glioblastoma cancers as compared to control samples. Discussion and Conclusion: aEuro,Our results suggest that plasma netrin-1 can be used as a diagnostic biomarker for many human cancers.
引用
收藏
页码：172 / 180
页数：9
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