Notch/LIN-12 signaling: transduction by regulated protein slicing

被引：25
|
作者：
Kimble, J
Henderson, S
Crittenden, S
机构：
[1] Univ Wisconsin, Mol Biol Lab, Madison, WI 53706 USA
[2] Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA
[3] Univ Wisconsin, Dept Med Genet, Madison, WI 53706 USA
[4] Howard Hughes Med Inst, Madison, WI 53706 USA
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 1998年 / 23卷 / 09期
基金：
美国国家卫生研究院; 美国国家科学基金会;
关键词：
D O I：
10.1016/S0968-0004(98)01263-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Intercellular signaling through the Notch/LIN-12 transmembrane receptors regulates growth and differentiation during animal development. Moreover, defects in the conserved Notch/LIN-12 pathway are linked to human diseases. Here, we review models for two key steps in Notch/LIN-12 signaling: ligand-mediated activation of the receptor and receptor-mediated activation of transcription. Ligand binding appears to permit proteolysis of the receptor; as a result, the receptor's intracellular domain can enter the nucleus and function as a transcriptional co-activator.
引用
收藏
页码：353 / 357
页数：5
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