p53 and tumour viruses: Catching the guardian off-guard

被引：31
|
作者：
Neil, JC [1 ]
Cameron, ER [1 ]
Baxter, EW [1 ]
机构：
[1] UNIV GLASGOW, MOL ONCOL LAB, DEPT CLIN STUDIES, GLASGOW G61 1QH, LANARK, SCOTLAND
来源：
TRENDS IN MICROBIOLOGY | 1997年 / 5卷 / 03期
关键词：
D O I：
10.1016/S0966-842X(96)10083-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Oncogenic viruses have evolved direct and indirect mechanisms to overcome the tumour suppressor p53. Fortunately, tumour development is limited by the narrow cell tropisms of the viruses concerned and the host immune response. However, such viruses are helping to elucidate the p53 response pathway and may play a future role as novel cancer therapeutic agents.
引用
收藏
页码：115 / 120
页数：6
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