Fine-tuning of the innate immune response by microRNAs

被引：85
|
作者：
Gantier, Michael P.
Sadler, Anthony J.
Williams, Bryan Rg
机构：
[1] Monash Med Ctr, Monash Inst Med Res, Clayton, Vic 3168, Australia
[2] Monash Univ, Monash Inst Med Res, Ctr Canc Res, Clayton, Vic 3168, Australia
来源：
IMMUNOLOGY AND CELL BIOLOGY | 2007年 / 85卷 / 06期
关键词：
innate immunity; microRNAs; RNA interference;
D O I：
10.1038/sj.icb.7100091
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
MicroRNAs ( miRNAs) are emerging as potent regulators of many biological processes, including cellular differentiation and disease. Recently, miRNA has been directly involved in innate immunity and transduction signalling by Toll-like receptors and the ensuing cytokine response. In this review, we present an overview of what is currently known of the involvement of miRNA and RNA interference components in the fine-tuning of innate immune responses.
引用
收藏
页码：458 / 462
页数：5
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