A convenient hydroiodination of alkynes using I2/PPh3/H2O and its application to the one-pot synthesis of trisubstituted alkenes via iodoalkenes using Pd-catalyzed cross-coupling reactions

被引：23

作者：

Kawaguchi, Shin-ichi ^{[1
]}

Gonda, Yuhei ^{[1
]}

Masuno, Haruna ^{[1
]}

Hue Thi Vu ^{[1
]}

Yamaguchi, Kotaro ^{[1
]}

Shinohara, Hiroyuki ^{[1
]}

Sonoda, Motohiro ^{[1
]}

Ogawa, Akiya ^{[1
]}

机构：

[1] Osaka Prefecture Univ, Grad Sch Engn, Dept Appl Chem, Naka Ku, Sakai, Osaka 5998531, Japan

来源：

TETRAHEDRON LETTERS | 2014年 / 55卷 / 50期

关键词：

Hydroiodination; Cross-coupling reactions; Trisubstituted alkenes; Phosphorus reagents; One-pot synthesis; PALLADIUM; HYDROGEN; SYSTEM; IODINE; ARYL; ACETYLENES; GENERATION; REAGENTS; ADDUCTS; IODIDES;

D O I：

10.1016/j.tetlet.2014.10.039

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile hydroiodination of alkynes using readily-available reagents such as I-2, PPh3, and H2O has been developed. This is extended to the one-pot synthesis of trisubstituted alkenes from alkynes via iodoalkenes using Pd-catalyzed cross-coupling and related methods such as the Suzuki-Miyaura cross-coupling, Sonogashira cross-coupling reaction, and Mizoroki-Heck reaction. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：6779 / 6783

页数：5

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