NATURAL TETRAHYDROCURCUMIN IN MULTI-COMPONENT SYNTHESIS OF 1,4-DIHYDROPYRIDINE DERIVATIVES

被引：0
|
作者：
Yutthaseri, Thatsawan [1 ,2 ]
Ajavakom, Anawat [3 ]
Ajavakom, Vachiraporn [1 ,2 ]
机构：
[1] Ramkhamhang Univ, Fac Sci, Dept Chem, Bangkok 10240, Thailand
[2] Ramkhamhang Univ, Fac Sci, Ctr Excellence Innovat Chem, Bangkok 10240, Thailand
[3] Chulalongkorn Univ, Fac Sci, Nanotec CU Ctr Excellence Food & Agr, Dept Chem, Bangkok 10330, Thailand
来源：
HETEROCYCLES | 2016年 / 92卷 / 08期
关键词：
ONE-POT SYNTHESIS; HANTZSCH REACTION; CURCUMIN ANALOGS; ANTIMICROBIAL ACTIVITY; ANTICANCER AGENTS; EFFICIENT; POLYHYDROQUINOLINE; CATALYST; CELLS; ANTIOXIDANT;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The mild condition synthesis of tetrahydrocurcumin- (THC-) dihydropyridine (DHP) was achieved by using the multi-component Hantzsch reaction in the presence of the catalytic amount of p-toluenesulfonic acid and 4 angstrom molecular sieves as a dehydrating agent. The successfully isolated intermediate, enaminone-THC, was the key component to reveal the reaction mechanism of this modified Hantzsch reaction. Due to containing the phenolic diarylheptanoid moiety, these novel heterocycles, THC-DHPs, are expected to exhibit interesting therapeutic properties.
引用
收藏
页码：1512 / 1520
页数：9
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