Research on endoplasmic reticulum-targeting fluorescent probes and endoplasmic reticulum stress-mediated nanoanticancer strategies: A review

被引：20
|
作者：
Qiao, Li [1 ]
Shao, Xinxin [2 ]
Gao, Shijie [1 ]
Ming, Zheng [3 ]
Fu, Xianjun [2 ]
Wei, Qingcong [4 ]
机构：
[1] Shandong Univ Tradit Chinese Med, Expt Ctr, Jinan 250355, Peoples R China
[2] Shandong Univ Tradit Chinese Med, Lab Tradit Chinese Med Network Pharmacol, Jinan 250355, Peoples R China
[3] Shandong Univ Tradit Chinese Med, Int Off, Jinan, Peoples R China
[4] Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China
来源：
COLLOIDS AND SURFACES B-BIOINTERFACES | 2021年 / 208卷
关键词：
Endoplasmicreticulum-targeting; Fluorescent probe; Nanotechnology; Endoplasmic reticulum stress; Cell apoptosis; IMMUNOGENIC CELL-DEATH; UNFOLDED PROTEIN RESPONSE; HYPOCHLOROUS ACID HCLO; RECENT PROGRESS; ER-STRESS; SELECTIVE DETECTION; CARBOXYLESTERASE; HYDROGEN-SULFIDE; IRON HOMEOSTASIS; CANCER;
D O I：
10.1016/j.colsurfb.2021.112046
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
Subcellular localization of organelles can achieve accurate drug delivery and maximize drug efficacy. As the largest organelle in eukaryotic cells, the endoplasmic reticulum (ER) plays an important role in protein synthesis, folding, and posttranslational modification; lipid biosynthesis; and calcium homeostasis. Observing the changes in various metal ions, active substances, and the microenvironment in the ER is crucial for diagnosing and treating many diseases, including cancer. Excessive endoplasmic reticulum stress (ERS) can have a killing effect on malignant cells and can mediate cell apoptosis, proper modulation of ERS can provide new perspectives for the treatment of many diseases, including cancer. Therefore, the ER is used as a new anticancer target in cancer treatment. This review discusses ER-targeting fluorescent probes and ERS-mediated nanoanticancer strategies.
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页数：12
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