Block copolymer vesicles containing paramagnetic lanthanide complexes: a novel class of T1- and CEST MRI contrast agents

被引：20

作者：

Grull, Holger ^{[1
,2
]}

Langereis, Sander ^{[1
]}

Messager, Lea ^{[1
]}

Castelli, Daniela Delli ^{[3
,4
]}

Sanino, Alberto ^{[3
,4
]}

Torres, Elena ^{[3
,4
]}

Terreno, Enzo ^{[3
,4
]}

Aime, Silvio ^{[3
,4
]}

机构：

[1] Philips Res Europe, NL-5656 AE Eindhoven, Netherlands

[2] Eindhoven Univ Technol, NL-5600 MB Eindhoven, Netherlands

[3] Dipartimento Chim IFM, I-10125 Turin, Italy

[4] Mol Imaging Ctr, I-10125 Turin, Italy

来源：

SOFT MATTER | 2010年 / 6卷 / 19期

关键词：

EXCHANGE SATURATION-TRANSFER; POROUS POLYMERSOMES; IN-VIVO; LIPOSOMES; WATER; PERMEABILITY; PROTONS; FIELD; DRUG;

D O I：

10.1039/c0sm00345j

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Block copolymer vesicles containing paramagnetic lanthanide complexes represent a versatile class of MRI contrast agents. By exploiting the water flux across the membrane, these nanovesicles can be employed as T-1- and CEST MRI contrast agents. The incorporation of paramagnetic amphiphilic lipids (Gd-1 for T-1 MRI CAs agents and Tm-2 for CEST MRI CAs) into the polymeric bilayer markedly improves the properties of the MRI contrast agents with respect to the longitudinal relaxivity (22 mM(-1) s(-1) at 20 MHz) and the chemical shift of the intrapolymersomal water protons.

引用

页码：4847 / 4850

页数：4

共 30 条

[21] Hybrid lanthanide nanoparticles as a new class of binary contrast agents for in vivo T1/T2 dual-weighted MRI and synergistic tumor diagnosis (vol 4, pg 2715, 2016)
Yi, Zhigao
Li, Xiaolong
Lu, Wei
Liu, Hongrong
Zeng, Songjun
Hao, Jianhua
JOURNAL OF MATERIALS CHEMISTRY B, 2023, 11 (40) : 9765 - 9765
[22] Dual T1/T2 Nanoscale Coordination Polymers as Novel Contrast Agents for MRI: A Preclinical Study for Brain Tumor
Suarez-Garcia, S.
Arias-Ramos, N.
Frias, C.
Candiota, A. P.
Arus, C.
Lorenzo, J.
Ruiz-Molina, D.
Novio, F.
ACS APPLIED MATERIALS & INTERFACES, 2018, 10 (45) : 38819 - 38832
[23] T1-T2 Dual-modal MRI contrast agents based on superparamagnetic iron oxide nanoparticles with surface attached gadolinium complexes
Szpak, Agnieszka
Fiejdasz, Sylwia
Prendota, Witold
Straczek, Tomasz
Kapusta, Czeslaw
Szmyd, Janusz
Nowakowska, Maria
Zapotoczny, Szczepan
JOURNAL OF NANOPARTICLE RESEARCH, 2014, 16 (11)
[24] T1–T2 Dual-modal MRI contrast agents based on superparamagnetic iron oxide nanoparticles with surface attached gadolinium complexes
Agnieszka Szpak
Sylwia Fiejdasz
Witold Prendota
Tomasz Strączek
Czesław Kapusta
Janusz Szmyd
Maria Nowakowska
Szczepan Zapotoczny
Journal of Nanoparticle Research, 2014, 16
[25] Gadolinium-conjugated star-block copolymer polylysine-modified polyethylenimine as highperformance T1 MR imaging blood pool contrast agents
Huang, Zhongjie
Chen, Yicun
Liu, Daojun
Lu, Chao
Shen, Zhiwei
Zhong, Shuping
Shi, Ganggang
RSC ADVANCES, 2018, 8 (09): : 5005 - 5012
[26] Comprehensive Evaluation of the Physicochemical Properties of LnIII Complexes of Aminoethyl-DO3A as pH-Responsive T1-MRI Contrast Agents
Baranyai, Zsolt
Rolla, Gabriele A.
Negri, Roberto
Forgacs, Attila
Giovenzana, Giovanni B.
Tei, Lorenzo
CHEMISTRY-A EUROPEAN JOURNAL, 2014, 20 (10) : 2933 - 2944
[27] Lanthanide complexes based on a 1,7-diaza-12-crown-4 platform containing picolinate pendants:: A new structural entry for the design of magnetic resonance imaging contrast agents
Mato-Iglesias, Marta
Roca-Sabio, Adrian
Palinkas, Zoltan
Esteban-Gomez, David
Platas-Iglesias, Carlos
Toth, Eva
de Blas, Andres
Rodriguez-Blas, Teresa
INORGANIC CHEMISTRY, 2008, 47 (17) : 7840 - 7851
[28] Aptamer-PEG-modified Fe3O4@Mn as a novel T1- and T2- dual-model MRI contrast agent targeting hypoxia-induced cancer stem cells
Haitao Zhu
Lirong Zhang
Yanfang Liu
Yuepeng Zhou
Kang Wang
Xiaodong Xie
Lian Song
Dongqing Wang
Chunlei Han
Qiuyun Chen
Scientific Reports, 6
[29] Complexes of selected late period lanthanide(III) cations with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid amide (DOTAM)-alkyl ligands - A new platform for the development of paramagnetic chemical exchange saturation transfer (PARACEST) magnetic resonance imaging (MRI) contrast agents
Elmehriki, Adam A. H.
Milne, Mark
Suchy, Mojmir
Bartha, Robert
Hudson, Robert H. E.
CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 2013, 91 (03): : 211 - 219
[30] Polyion complex micelle MRI contrast agents from poly(ethylene glycol)-b-poly(L-lysine) block copolymers having Gd-DOTA; preparations and their control of T1-relaxivities and blood circulation characteristics
Shiraishi, Kouichi
Kawano, Kumi
Maitani, Yoshie
Yokoyama, Masayuki
JOURNAL OF CONTROLLED RELEASE, 2010, 148 (02) : 160 - 167

← 1 2 3 →