Block copolymer vesicles containing paramagnetic lanthanide complexes: a novel class of T1- and CEST MRI contrast agents

被引：20

作者：

Grull, Holger ^{[1
,2
]}

Langereis, Sander ^{[1
]}

Messager, Lea ^{[1
]}

Castelli, Daniela Delli ^{[3
,4
]}

Sanino, Alberto ^{[3
,4
]}

Torres, Elena ^{[3
,4
]}

Terreno, Enzo ^{[3
,4
]}

Aime, Silvio ^{[3
,4
]}

机构：

[1] Philips Res Europe, NL-5656 AE Eindhoven, Netherlands

[2] Eindhoven Univ Technol, NL-5600 MB Eindhoven, Netherlands

[3] Dipartimento Chim IFM, I-10125 Turin, Italy

[4] Mol Imaging Ctr, I-10125 Turin, Italy

来源：

SOFT MATTER | 2010年 / 6卷 / 19期

关键词：

EXCHANGE SATURATION-TRANSFER; POROUS POLYMERSOMES; IN-VIVO; LIPOSOMES; WATER; PERMEABILITY; PROTONS; FIELD; DRUG;

D O I：

10.1039/c0sm00345j

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Block copolymer vesicles containing paramagnetic lanthanide complexes represent a versatile class of MRI contrast agents. By exploiting the water flux across the membrane, these nanovesicles can be employed as T-1- and CEST MRI contrast agents. The incorporation of paramagnetic amphiphilic lipids (Gd-1 for T-1 MRI CAs agents and Tm-2 for CEST MRI CAs) into the polymeric bilayer markedly improves the properties of the MRI contrast agents with respect to the longitudinal relaxivity (22 mM(-1) s(-1) at 20 MHz) and the chemical shift of the intrapolymersomal water protons.

引用

页码：4847 / 4850

页数：4

共 30 条

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