Post-condensational modifications of the Groebke-Blackburn-Bienayme reaction products for scaffold-oriented synthesis

被引：8
|
作者：
Krasavin, Mikhail [1 ]
Dar'in, Dmitry
Balalaie, Saeed
机构：
[1] St Petersburg State Univ, Inst Chem, Peterhof 198504, Russia
来源：
TETRAHEDRON LETTERS | 2021年 / 86卷
基金：
美国国家科学基金会;
关键词：
Scaffold-oriented synthesis; Isocyanide-base multicomponent reactions; Post-condensational modifications; Groebke-Blackburn-Bienayme reaction; Polycyclic scaffolds; Contents; POT SEQUENTIAL SYNTHESIS; MULTICOMPONENT REACTIONS; 3-COMPONENT; HETEROCYCLES; PYRAZINES; DIVERSE; ACCESS;
D O I：
10.1016/j.tetlet.2021.153521
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Scaffold-generating transformations of the Groebke-Blackburn-Bienayme (GBB) reaction products are reviewed. The literature cases were grouped according to the reactions employed as the post -condensational event as follows: lactamization, intramolecular arylation, intramolecular Michael addition, cyclizations involving an alkyne moiety and miscellaneous. Although synthetic strategic based on the post-GBB modifications have been exploited to a lesser extent compared to post-Ugi modifications, the interest of researchers to the GBB reaction as the platform for designing new polycyclic scaffolds has been on the rise in the past decade. (c) 2021 Elsevier Ltd. All rights reserved.
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页数：15
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