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Expression of CD38 in human promyelocytic leukemia HL-60 cell line during differentiation by niacin-related compounds
被引:7
|作者:
Iwata, K
[1
]
Ogata, S
[1
]
Okumura, K
[1
]
Taguchi, H
[1
]
机构:
[1] Mie Univ, Fac Bioresources, Dept Life Sci, Mol & Cellular Biol Lab, Tsu, Mie 5148507, Japan
关键词:
CD38;
niacin;
isonicotinic acid;
cell differentiation;
HL-60;
D O I:
10.1271/bbb.67.1836
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
It was found that three niacin-related compounds, isonicotinic acid, nicotinamide, and nicotifiamide N-oxide, induced granulocytic differentiation in HL-60 cells. We investigated the expression of CD38, which catalyzes the synthesis of cyclic ADP-ribose, a Ca2+ mobilizer, during differentiation by niacin-related compounds. It was found that CD38 was induced by isonicotinic acid, whereas nicotinamide and nicotinamide N-oxide containing an amino group did not induce it. The difference in expression of CD38 may provide some useful information for the elucidation of the mechanisms of cell differentiation.
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页码:1836 / 1839
页数:4
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