Expression of CD38 in human promyelocytic leukemia HL-60 cell line during differentiation by niacin-related compounds

被引：7
|
作者：
Iwata, K [1 ]
Ogata, S [1 ]
Okumura, K [1 ]
Taguchi, H [1 ]
机构：
[1] Mie Univ, Fac Bioresources, Dept Life Sci, Mol & Cellular Biol Lab, Tsu, Mie 5148507, Japan
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2003年 / 67卷 / 08期
关键词：
CD38; niacin; isonicotinic acid; cell differentiation; HL-60;
D O I：
10.1271/bbb.67.1836
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
It was found that three niacin-related compounds, isonicotinic acid, nicotinamide, and nicotifiamide N-oxide, induced granulocytic differentiation in HL-60 cells. We investigated the expression of CD38, which catalyzes the synthesis of cyclic ADP-ribose, a Ca2+ mobilizer, during differentiation by niacin-related compounds. It was found that CD38 was induced by isonicotinic acid, whereas nicotinamide and nicotinamide N-oxide containing an amino group did not induce it. The difference in expression of CD38 may provide some useful information for the elucidation of the mechanisms of cell differentiation.
引用
收藏
页码：1836 / 1839
页数：4
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