The Ca2+/Mn2+ pumps in the Golgi apparatus

Recent evidence highlights the functional importance of the Golgi apparatus as an agonist-sensitive intracellular Ca2+ store. Besides Ca2+-release channels and Ca2+-binding proteins, the Golgi complex contains Ca2+-uptake mechanisms consisting of the well-known sarco/endoplasmic reticulum Ca2+-transport ATPases (SERCA) and the much less characterized secretory-pathway Ca2+-transport ATPases (SPCA). SPCA supplies the Golgi compartments and, possibly, the more distal compartments of the secretory pathway with both Ca2+ and Mn2+ and, therefore, plays an important role in the cytosolic and intra-Golgi Ca2+ and Mn2+ homeostasis. Mutations in the human gene encoding the SPCA1 pump (ATP2C1) resulting in Hailey-Hailey disease, an autosomal dominant skin disorder, are discussed. (C) 2004 Elsevier B.V. All rights reserved.