The Aspergillus fumigatus P-Type Golgi Apparatus Ca2+/Mn2+ ATPase PmrA Is Involved in Cation Homeostasis and Cell Wall Integrity but Is Not Essential for Pathogenesis

被引：39

作者：

Pinchai, Nadthanan ^{[3
]}

Juvvadi, Praveen Rao

Fortwendel, Jarrod R. ^{[2
]}

Perfect, B. Zachary

Rogg, Luise E.

Asfaw, Yohannes G. ^{[4
]}

Steinbach, William J. ^{[1
,2
]}

机构：

[1] Duke Univ, Med Ctr, Div Pediat Infect Dis, Dept Pediat, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Durham, NC 27710 USA

[3] Mahidol Univ, Siriraj Hosp, Dept Microbiol, Fac Med, Bangkok 10700, Thailand

[4] Duke Univ, Med Ctr, Dept Lab Anim Resources, Durham, NC 27710 USA

来源：

EUKARYOTIC CELL | 2010年 / 9卷 / 03期

关键词：

YEAST SECRETORY PATHWAY; ZINC-FINGER PROTEIN; SACCHAROMYCES-CEREVISIAE; CANDIDA-ALBICANS; PLASMA-MEMBRANE; SALT TOLERANCE; HYPHAL GROWTH; CALCINEURIN; GENE; HOMOLOG;

D O I：

10.1128/EC.00378-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The Aspergillus fumigatus Delta pmrA (Golgi apparatus Ca2+/Mn2+ P-type ATPase) strain has osmotically suppressible basal growth defects and cationic tolerance associated with increased expression of calcineurin pathway genes. Despite increased beta-glucan and chitin content, it is hypersensitive to cell wall inhibitors but remains virulent, suggesting a role for PmrA in cation homeostasis and cell wall integrity.

引用

页码：472 / 476

页数：5

共 8 条

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