A Short Synthesis of Bisabolane Sesquiterpenes

被引：12
|
作者：
Du, Zhen-Ting [1 ,2 ]
Zheng, Shuai [1 ]
Chen, Gang [1 ]
Lv, Dong [1 ]
机构：
[1] NW A&F Univ, Coll Sci, Yangling 712100, Shaanxi, Peoples R China
[2] Talimu Univ, Key Lab Protect & Utilizat Biol Resources Tarim B, Alaer 843300, Xinjiang, Peoples R China
来源：
MOLECULES | 2011年 / 16卷 / 09期
基金：
中国国家自然科学基金;
关键词：
curcumene; xanthorrhizol; curcuhydroquinone; synthesis; MEDIATED ENANTIOSELECTIVE SYNTHESIS; CLAISEN REARRANGEMENT APPROACH; CURCUMA-XANTHORRHIZA; ASYMMETRIC-SYNTHESIS; NATURAL-PRODUCTS; (+/-)-CURCUPHENOL; ACID; (+/-)-CURCUHYDROQUINONE; (+)-ALPHA-CURCUMENE; (-)-XANTHORRHIZOL;
D O I：
10.3390/molecules16098053
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A facile total synthesis of three members of the bisabolane sesquiterpene family, namely (+/-)-curcumene, (+/-)-xanthorrhizol and (+/-)-curcuhydroquinone had been achieved in high overall yield. The synthesis used bromobenzene derivatives as starting materials. The halogen-lithium exchange followed by addition of isoprenylacetone and reduction of the obtained carbinols are the key steps of the synthetic pathway. This synthetic approach provides a new route to the bisabolane sesquiterpenes.
引用
收藏
页码：8053 / 8061
页数：9
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