Self-renewal related signaling in myeloid leukemia stem cells

被引：33
|
作者：
Heidel, Florian H. [1 ,2 ,3 ]
Mar, Brenton G. [1 ,2 ]
Armstrong, Scott A. [1 ,2 ,4 ]
机构：
[1] Childrens Hosp, Div Hematol Oncol, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA
[3] Otto VonGuericke Univ Magdegurg, Dept Hematol Oncol, D-39016 Magdeburg, Germany
[4] Harvard Univ, Stem Cell Inst, Boston, MA 02115 USA
来源：
INTERNATIONAL JOURNAL OF HEMATOLOGY | 2011年 / 94卷 / 02期
关键词：
Leukemia stem cell; Self-renewal; Hedgehog; Wnt; Notch; FoxO; CHRONIC MYELOGENOUS LEUKEMIA; COMPLETE MOLECULAR REMISSION; INHIBITS TUMOR-GROWTH; BETA-CATENIN; IN-VIVO; BCR-ABL; SONIC HEDGEHOG; CANCER; NOTCH; PATHWAY;
D O I：
10.1007/s12185-011-0901-0
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A key characteristic of hematopoietic stem cells (HSC) is the ability to self-renew. Several genes and signaling pathways control the fine balance between self-renewal and differentiation in HSC and potentially also in leukemic stem cells. Besides pathways such as Wnt signaling, Hedgehog signaling and Notch signaling, transcription factors (FoxOs) and cell fate determinants may also play a role in stem cells. While some of these pathways seem to be dispensable for maintenance of adult HSC, there may be a distinct requirement in leukemia stem cells for leukemic self-renewal. Here we will focus on self-renewal related signaling in myeloid leukemia stem cells and its therapeutic relevance.
引用
收藏
页码：109 / 117
页数：9
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