Safety and efficacy of autologous stem cell implantation for spinal cord traumatic injury repair

被引：0

作者：

Hadjianev, A. ^{[1
]}

Botev, C. ^{[2
]}

Bussarsky, V. ^{[1
]}

Romansky, K. ^{[1
]}

Mirchev, N. ^{[1
]}

Georgiev, K. ^{[1
]}

Nuchev, L. ^{[1
]}

Djendov, St. ^{[1
]}

Iliev, I. ^{[1
]}

Tonev, I. ^{[2
]}

Altankova, I. ^{[3
]}

Genova, M. ^{[2
]}

Hrischev, V. ^{[2
]}

Kiurktchiev, D. ^{[3
]}

Shivarov, V. ^{[2
]}

Oncheva, G. ^{[3
]}

Shopova, I. ^{[3
]}

Georgiev, G. ^{[2
]}

Boteva, E. ^{[4
]}

Hristova, S. ^{[4
]}

Slavov, P. ^{[4
]}

Mincheff, M. ^{[2
]}

机构：

[1] Aleksandrovska & St Ivan Rilski Univ Hosp, Neurosurg Clin, Sofia, Bulgaria

[2] Natl Ctr Hematol & Blood Transfus, Sofia, Bulgaria

[3] St Ivan Rilski Univ Hosp, Cent Immunol Lab, Sofia, Bulgaria

[4] Procell Med Ctr, Sofia, Bulgaria

来源：

PROCEEDINGS OF THE 13TH EUROPEAN CONGRESS OF NEUROSURGERY | 2007年

关键词：

D O I：

暂无

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Background: Regenerative therapy by autologous stem cell implantation may benefit patients with traumatic spinal cord (SCI). Aims: The aim of this study was to analyze the safety efficacy of autologous stem cell implantation for traumatic SCI in a clinical setting. Patients and Methods: Seventy four patients, age between 18 and 65 (median 43), were included in the study. Fifteen to 40x 10(6) CD34+ cells per patient were implanted. The implantation of the stem cells followed routine neurosurgery procedures. Results: Implantation of the stem cells was tolerated very well and no serious side effects were noted. The lack of control and placebo groups hampers the interpretation of the efficacy analysis. There was, however, improvement in the sensory function in 69 of the 74 patients with SCI. Conclusion: The implantation of autologous stem cell for traumatic SCI is safe and well tolerated. Proper interpretation of the clinical efficacy necessitates a study that includes a control and a placebo groups.

引用

页码：595 / +

页数：2

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