Advances in Cellular Characterization of the Sirtuin lsoform, SIRT7

被引：59
|
作者：
Wu, Di [1 ,2 ]
Li, Yinglu [3 ]
Zhu, Kathy S. [4 ]
Wang, Haiying [1 ,5 ]
Zhu, Wei-Guo [3 ]
机构：
[1] Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci,Minist Educ, Key Lab Carcinogenesis & Translat Res,Beijing Key, Beijing, Peoples R China
[2] Peking Univ, Inst Syst Biomed, Sch Basic Med Sci, Hlth Sci Ctr, Beijing, Peoples R China
[3] Shenzhen Univ, Hlth Sci Ctr, Dept Biochem & Mol Biol, Shenzhen, Peoples R China
[4] Peking Univ, Sch Publ Hlth, Hlth Sci Ctr, Beijing, Peoples R China
[5] Peking Univ, Sch Basic Med Sci, Hlth Sci Ctr, Dept Biochem & Mol Biol, Beijing, Peoples R China
来源：
FRONTIERS IN ENDOCRINOLOGY | 2018年 / 9卷
基金：
中国国家自然科学基金;
关键词：
SIRT7; rDNA transcription; ribosome biogenesis; cellular stress; metabolism; aging; genome stability; cancer; RNA-POLYMERASE I; HEPATOCELLULAR-CARCINOMA; H3K18; DEACETYLATION; STRESS-RESPONSE; DOWN-REGULATION; PROTEIN SIR2; 7; EXPRESSION; INHIBITION; DNA; NUCLEAR;
D O I：
10.3389/fendo.2018.00652
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
SIRT7 is one of seven mammalian sirtuins that functions as an NAD(+)-dependent histone/protein deacetylase. SIRT7 is the least well-known member of the sirtuin family, but recent efforts have identified its involvement in various cellular processes, such as ribosome biogenesis, gene expression, cellular metabolism and cancer. Here we provide an update on the functions and mechanisms of SIRT7 in cellular regulation and disease.
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页数：13
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