Novel Thiopurine Methyltransferase Variant TPMT*28 Results in a Misdiagnosis of TPMT Deficiency

被引：0
|
作者：
Landy, J. [1 ]
Bhuva, N. [1 ]
Marinaki, A. [2 ]
Mawdsley, J. [1 ]
机构：
[1] W Middlesex Univ Hosp, Dept Gastroenterol, Isleworth, England
[2] GSTS Pathol Guys St Thomas NHS Fdn Trust, Purine Res Lab, London, England
来源：
INFLAMMATORY BOWEL DISEASES | 2011年 / 17卷 / 06期
关键词：
AZATHIOPRINE; DISEASE;
D O I：
10.1002/ibd.21505
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
引用
收藏
页码：1441 / 1442
页数：2
相关论文
共 50 条
  • [21] Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT*3A, TPMT*2): Mechanisms for the genetic polymorphism of TPMT activity
    Tai, HL
    Krynetski, EY
    Schuetz, EG
    Yanishevski, Y
    Evans, WE
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (12) : 6444 - 6449
  • [22] TPMT Assessment Prior to Initiation of Thiopurine Therapy: Results and the Impact of TPMT on Starting Dose
    Wysocki, John
    Mehmood, Faisal
    Khan, Nabeel
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 2015, 110 : S828 - S828
  • [23] Pitfalls in the determination of mutant alleles of the thiopurine methyltransferase (TPMT) gene: does TPMT*3B exist?
    Brouwer, C
    Marinaki, TM
    Lambooy, LHJ
    Duley, JA
    Shobowale-Bakre, M
    De Abreu, RA
    LEUKEMIA, 2001, 15 (03) : 496 - 496
  • [24] Allelic variants of the thiopurine methyltransferase (TPMT) gene in the Colombian population
    Isaza, C
    Henao, J
    López, AM
    Cacabelos, R
    METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY, 2003, 25 (06): : 423 - 429
  • [25] Genetic Mutations of Thiopurine-Methyltransferase (TPMT) in Inflammatory Bowel Disease Patients With Normal TPMT Phenotype and Thiopurine-Induced Myelotoxicity
    Chaparro, Maria
    de Parga, Paula Vazquez
    Van Domselaar, Manuel
    Garcia, Raquel
    Algaba, Alicia
    Martinez, Pilar
    Vera, Isabel
    Marin-Jimenez, Ignacio
    Diaz, Angel Ponferrada
    Roman, Manuel
    Taxonera, Carlos
    Roman, Antonio Lopez-San
    Lopez-Serrano, Pilar
    Bermejo, Fernando
    Casis, Begona
    Gonzalez-Lama, Yago
    Abad-Santos, Francisco
    Nogueiras, Amelia Rodriguez
    Mate, Jose
    Gisbert, Javier P.
    GASTROENTEROLOGY, 2010, 138 (05) : S686 - S686
  • [26] Thiopurine S-methyltransferase (TPMT) genetic polymorphisms in Mexican newborns
    Gonzalez-del Angel, A.
    Bermudez-Lopez, C.
    Alcantara-Ortigoza, M. A.
    Vela-Amieva, M.
    Castillo-Cruz, R. A.
    Martinez, V.
    Torres-Espindola, L.
    JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 2009, 34 (06) : 703 - 708
  • [27] Thiopurine S-methyltransferase (TPMT) pharmacogenetics: Role of chaperone proteins in variant allozyme degradation.
    Wang, L
    Sullivan, W
    Toft, D
    Weinshilboum, R
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2003, 73 (02) : P29 - P29
  • [28] MONITORING THIOPURINE METHYLTRANSFERASE (TPMT) ACTIVITY IN INFLAMMATORY BOWEL DISEASE: IS IT WORTH IT?
    Gledhill, T.
    Hurst, A.
    Brown, L.
    Bliss, P.
    GUT, 2011, 60 : A145 - A145
  • [29] TPMT (thiopurine methyltransferase) genotype-phenotype accuracy in IBD patients
    Taylor, E
    Matsutani, M
    Barry, M
    Bogardt, R
    Wassman, ER
    GASTROENTEROLOGY, 2002, 122 (04) : A222 - A222
  • [30] Different thiopurine methyltransferase (TPMT) alleles in Caucasian and Asian populations.
    Collie-Duguid, ESR
    Pritchard, SC
    Sludden, J
    Collier, D
    Li, T
    McLeod, HL
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 1998, 63 (02) : 148 - 148
12345