Purpose of review The aim is to assess the evidence in support of home-based versus clinic-based screening for sexually transmitted infections. Recent findings Home-based screening for sexually transmitted infections has been shown to be a feasible approach for men and women from a variety of settings, including high-risk, low-income, and resource-poor communities. In recent studies, the testing rate with home-based screening was up to 11 times greater than the testing rate with clinic-based screening. For most individuals, self-collection and testing of urine or vaginal specimens at home was considered to be easy, acceptable, and often preferred over testing at a clinic. There is limited evidence with regard to the cost effectiveness of home-based versus clinic-based screening for sexually transmitted infections. However, a study from the United States concluded that home-based screening is cost saving. Summary Improvements in screening rates for sexually transmitted infections can be achieved with home-based screening methods. Making low-cost home test kits available may encourage at-risk young individuals with less access to clinic care, who may not otherwise be screened, to self-test for sexually transmitted infections.