Brain-Derived Neurotrophic Factor Systemic Response in the Periodontium, Trigeminal Nucleus Caudalis, and Hippocampus Induced by Occlusal Trauma

被引：0
|
作者：
Liu, Di [1 ,2 ,3 ]
Li, Ying [4 ,5 ]
Liu, Jiechen [1 ,2 ,3 ]
Shen, Zhiyuan [1 ,2 ,3 ]
Wang, Fengying [1 ,2 ,3 ]
Li, Qing [1 ,2 ,3 ]
机构：
[1] Shandong Univ, Sch & Hosp Stomatol, Cheeloo Coll Med, Jinnan 250012, Shandong, Peoples R China
[2] Shandong Key Lab Oral Tissue Regenerat, Jinnan 250012, Shandong, Peoples R China
[3] Shandong Engn Lab Dent Mat & Oral Tissue Regenera, Jinnan 250012, Shandong, Peoples R China
[4] Shandong Univ, Qilu Hosp, Dept Geriatr Med, Jinnan 250012, Shandong, Peoples R China
[5] Shandong Univ, Qilu Hosp, Key Lab Cardiovasc Prote Shandong Prov, Jinan 250012, Shandong, Peoples R China
来源：
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY | 2021年 / 17卷 / 07期
基金：
中国博士后科学基金; 中国国家自然科学基金;
关键词：
Occlusal Trauma; Brain-Derived Neurotrophic Factor (BDNF); Tropomycin Receptor Kinase 8 (Trk 8); The Trigenminal Nucleus Caudalis (Vc); Hippocampus; BDNF; RAT; MASTICATION; EXPRESSION; HYDROGELS; ROLES; PAIN;
D O I：
10.1166/jbn.2021.3112
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Occlusal trauma (OT), by causing periodontal tissue damage, can activate and enhance the activity of the peripheral and central nervous system (CNS) neuropeptides. The brain-derived neurotrophic factor (BDNF) gene is activity-dependent and exhibits marked alterations, characterized by protection against injury and repair. Our results show the possible molecular mechanism through which noxious environmental stimuli induce alterations in BDNF activity in the local periodontal tissue, the primary sensory neurons-Vc, and the hippocampus, suggesting systemic impairment. BDNF serves a more positive and enduring trauma protection and repair function in Vc compared to that in local dental tissue.
引用
收藏
页码：1371 / 1379
页数：9
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