Extrasynaptic GABAA receptors in the crosshairs of hormones and ethanol

被引：28
|
作者：
Mody, Istvan [1 ]
机构：
[1] Univ Calif Los Angeles, David Geffen Sch Med, NRBI 575D, Dept Neurol, Los Angeles, CA 90095 USA
来源：
NEUROCHEMISTRY INTERNATIONAL | 2008年 / 52卷 / 1-2期
关键词：
GABA; inhibition; ovarian steroids; stress; ethanol;
D O I：
10.1016/j.neuint.2007.07.010
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Gamma-aminobutyric acid (GABA) is the main chemical inhibitory neurotransmitter in the brain. In the central nervous system (CNS) it acts on two distinct types of receptor: an ion channel, i.e., an "ionotropic" receptor permeable to Cl- and HCO3- (GABA(A) receptors) and a G-protein coupled "metabotropic" receptor that is linked to various effector mechanisms (GABA(B) receptors). This review will summarize novel developments in the physiology and pharmacology of GABA(A) receptors (GABA(A)Rs), specifically those found outside synapses. The focus will be on a particular combination of GABA(A)R subunits sensitive to ovarian and adrenal cortical steroid hormone metabolites that are synthesized in the brain (neurosteroids) and to sobriety impairing concentrations of ethanol. These receptors may be the final common pathway for interactions between ethanol and ovarian and stress-related neurosteroids. (C) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：60 / 64
页数：5
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