A MATHEMATICAL MODEL TO ASSESS THE IMMUNE RESPONSE AGAINST TRYPANOSOMA CRUZI INFECTION

被引：1

作者：

Yang, Hyun Mo ^{[1
]}

机构：

[1] UNICAMP IMECC DMA, BR-13083859 Campinas, SP, Brazil

来源：

JOURNAL OF BIOLOGICAL SYSTEMS | 2015年 / 23卷 / 01期

基金：

巴西圣保罗研究基金会;

关键词：

Chagas' Disease; Humoral and Cellular Immune Responses; Deterministic Model; Limit Cycle; CHAGAS-DISEASE; IMMUNIZATION; TRANSMISSION; ANTIBODIES; ANTIGEN; ELICITS;

D O I：

10.1142/S0218339015500084

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A mathematical model is developed to assess Immoral and cellular 411 MU. le responses against Trypanosoma cruzi infection. Analysis of the model shows a unique non-trivial equilibrium, which is locally asymptotically stable, except in the case of a strong cellular response. When the proliferation of the activated CD8 T cells is increased, this equilibrium becomes unstable and a limit cycle appears. However, this behavior can he avoided by increasing the action of the humoral response. Therefore, unbalanced humoral and cellular responses can be responsible for long asymptomatic period, and the control of Trypanosoma Cruzi infection is a consequence of well coordinated action of both humoral and cellular responses.

引用

页码：131 / 163

页数：33

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